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    Home > Natural Products > Iridoid Derivatives (Find 94 items)

    Iridoid Derivatives


    The main function is to stimulate the production of adrenal cortex hormones, thereby increasing the production of hormones. Catalpol also has anti-inflammatory activity and has been shown to increase the production of androgens produced by the adrenal glands, which leads to increased muscle mass.

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    Loganic acid is an iridoid isolated from cornelian cherry fruits. Loganic acid can modulate diet-induced atherosclerosis and redox status. Loganic acid has strong free radical scavenging activity and remarkable cyto-protective effect against heavy metal mediated toxicity[1][2].

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    Gardenoside is a natural compound found in Gardenia fruits, with hepatoprotective properties. Gardenoside suppresses the pain of chronic constriction injury by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis[1][2].

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    ChEBI: A iridoid monoterpenoid glycoside isolated from Galium verum.

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    8-O-acetyl shanzhiside methyl ester

    8-O-Acetyl shanzhiside methyl ester (ND01) is an iridoid glucoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant in Xi-zang. 8-O-Acetyl shanzhiside methyl ester could inhibt NF-κB.


    8-O-Acetylharpagide is an iridoid isolated from Ajuga reptans with antitumoral, antiviral, antibacterial, and anti-inflammatory activities. 8-O-Acetylharpagide also has a biological activity on isolated smooth muscle preparations from guinea pig[1][2].


    Shanzhiside methy lester is isolated from L. rotata. Shanzhiside methyl ester is a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist and has the ability to induce anti-allodynic tolerance[1].


    Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA)[1].

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    Sesamoside is a iridoid isolated from the aerial part of  Phlomis linearifolia. Sesamoside has antiodant and antiglycation activities[1].

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    Iridoids are derivatives of monoterpenes and occur usually, but not invariably, as glycosides. Iridoids and their glycoside derivatives are commonly found in a number of species of this genus including H. diffusa, H. hedyotidea, H. chrysotricha and H. corymbosa.
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