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    Home > Biochemical Engineering > Polypeptide (Find 243 items)



    Bivalirudin (Angiomax or Angiox, manufactured by The Medicines Company) is a specific and reversible direct thrombin inhibitor (DTI).Chemically, it is a synthetic congener of the naturally occurring drug hirudin (found in the saliva of the medicinal leech Hirudo medicinalis).Bivalirudin is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. Bivalirudin is a short, synthetic peptide that is potent, highly specific, and a reversible inhibitor of thrombin. It inhibits both circulating and clot-bound thrombin, while also inhibiting thrombin-mediated platelet activation and aggregation. Bivalirudin has a quick onset of action and a short half-life. It does not bind to plasma proteins (other than thrombin) or to red blood cells. Therefore, it has a predictable antithrombotic response. There is no risk for Heparin Induced Thrombocytopenia/Heparin Induced Thrombosis-Thrombocytopenia Syndrome (HIT/HITTS). It does not require a binding cofactor such as antithrombin and does not activate platelets. These characteristics make bivalirudin an ideal alternative to heparin.Bivalirudin clinical studies demonstrated consistent positive outcomes in patients with stable angina, unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) undergoing PCI in 7 major randomized trials. Patients receiving bivalirudin had fewer adverse events compared to patients that received heparin.

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    Atosiban is an oxytocin receptor blocking agent in the treatment of experimental endometriosis and was shown exhibit significant therapeutic efficiency.

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    Atropine isomeric diols have many uses: additives for asymmetric selective reduction of ketones; ligands in chiral titanium catalysts for stereoselective reactions, such as glyoxylic acid reaction, Diels-Alder reaction; Chiral auxiliary for catalyzing the asymmetric oxidation of sulfide to sulfoxide; chiral lanthanide trifluoromethanesulfonic acid from binaphthol, used as a catalyst in asymmetric Diels-Alder reaction; binaphthol Derivatives, recently discovered for asymmetric Claisen rearrangement reactions and asymmetric epoxidation reactions; the lithium aluminum hydride derivatives of these diols (BINAP-H) have been widely used in the reduction of ketones; chiral Precursor of binaphthol salt, a salt for asymmetric reaction of olefin epoxidation
    Polypeptide is a compound formed by connecting α-amino acids with peptide bonds, and is an intermediate product of protein hydrolysis. Compounds usually formed by the dehydration and condensation of 10 to 100 amino acid molecules are called peptides. There are two types of peptides: biologically active peptides and synthetic peptides.
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