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    Home > API > Circulatory System Drugs > Ramipril
    Ramipril

    Ramipril

    • CAS No:

      87333-19-5

    • Formula:

      C23H32N2O5

    Basic Attributes
    • 87333-19-5

    • C23H32N2O5

    • 416.51

    Characteristics
    • white

    • 106-108°C

    • DMSO: ~18mg/mL

    • 2-8°C

    Safety Information
    • 36/38

    • 26-37/39

    • GY5879600

    • Xi

    Product Usage

    Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes. Ramipril is a second generation ACE inhibitor (IC50 = 4 nM) that acts as a prodrug, which is hydrolyzed in vivo to the active metabolite ramiprilat. The antihypertensive and cardioprotective efficacy of ramipril has been demonstrated in large-scale noncomparative studies and clinical trials.[Cayman Chemical]

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