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    Home > PYRIDINE-D5 SDS

    PYRIDINE-D5 Safety Data Sheets


    According to the UN GHS revision 8

    Version: 1.0

    Creation Date: July 15, 2019

    Revision Date: July 15, 2019

    SECTION 1: Identification

    1.1 GHS Product identifier

    Product name


    1.2 Other means of identification

    Product number


    Other names


    1.3 Recommended use of the chemical and restrictions on use

    Identified uses

    Benzidines/Aromatic amines

    Uses advised against

    no data available

    1.4 Supplier's details




    1.5 Emergency phone number

    Emergency phone number

    Service hours

    Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    SECTION 2: Hazard identification

    2.1 Classification of the substance or mixture

    Flammable liquids, Category 2

    Acute toxicity - Category 4, Oral

    Acute toxicity - Category 4, Dermal

    Skin irritation, Category 2

    Eye irritation, Category 2

    Acute toxicity - Category 4, Inhalation

    2.2 GHS label elements, including precautionary statements

    Signal word


    Hazard statement(s)

    H225 Highly flammable liquid and vapour

    H302+H312+H332 Harmful if swallowed, in contact with skin or if inhaled

    H315 Causes skin irritation

    H319 Causes serious eye irritation

    Precautionary statement(s)

    P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

    P233 Keep container tightly closed.

    P240 Ground and bond container and receiving equipment.

    P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment.

    P242 Use non-sparking tools.

    P243 Take action to prevent static discharges.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P271 Use only outdoors or in a well-ventilated area.


    P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower].

    P370+P378 In case of fire: Use ... to extinguish.

    P301+P317 IF SWALLOWED: Get medical help.

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P317 Get medical help.

    P321 Specific treatment (see ... on this label).

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P332+P317 If skin irritation occurs: Get medical help.

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.


    P403+P235 Store in a well-ventilated place. Keep cool.


    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    2.3 Other hazards which do not result in classification

    no data available

    SECTION 3: Composition/information on ingredients

    3.1 Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    (2H5)pyridine (2H5)pyridine 7291-22-7 230-720-2 100%

    SECTION 4: First-aid measures

    4.1 Description of necessary first-aid measures

    If inhaled

    Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

    Following skin contact

    Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

    Following eye contact

    First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

    Following ingestion

    Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

    4.2 Most important symptoms/effects, acute and delayed

    Vapor irritates eyes and nose. Liquid irritates skin and is absorbed through the skin. Overexposure causes nausea, headache, nervous symptoms, increased urinary frequency. (USCG, 1999)

    4.3 Indication of immediate medical attention and special treatment needed, if necessary

    Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal . Aromatic hydrocarbons and related compounds

    SECTION 5: Fire-fighting measures

    5.1 Suitable extinguishing media

    Use water spray, dry chemical, "alcohol resistant" foam, or carbon dioxide. Solid streams of water may be ineffective. Use water spray to keep fire-exposed containers cool.

    5.2 Specific hazards arising from the chemical

    Behavior in Fire: Vapor is heavier than air and may travel considerable distance to source of ignition and flash back. (USCG, 1999)

    5.3 Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    SECTION 6: Accidental release measures

    6.1 Personal precautions, protective equipment and emergency procedures

    Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

    6.2 Environmental precautions

    Personal protection: self-contained breathing apparatus. Remove all ignition sources. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

    6.3 Methods and materials for containment and cleaning up

    1. remove all ignition sources. 2. ventilate area of spill or leak. 3. for small quantities, absorb on paper towels, evaporate in safe place (such as fume hood). allow sufficient time for evaporating vapors to completely clear hood ductwork. burn paper in suitable location away from combustible material. 3. large quantities can be collected & atomized in suitable combustion chamber equipped with appropriate effluent gas cleaning device. pyridine should not be allowed to enter confined space, such as sewer, because of possibility of explosion.

    SECTION 7: Handling and storage

    7.1 Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    7.2 Conditions for safe storage, including any incompatibilities

    Fireproof. Separated from strong oxidants and strong acids. Cool. Dry. Well closed.OUTSIDE OR DETACHED STORAGE IS PREFERABLE. ISOLATE FROM POWERFUL OXIDIZING MATERIALS AND ACIDS.

    SECTION 8: Exposure controls/personal protection

    8.1 Control parameters

    Occupational Exposure limit values

    Component (2H5)pyridine
    CAS No. 7291-22-7

    Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 5 ppm (15 mg/cu m).

    Biological limit values

    no data available

    8.2 Appropriate engineering controls

    Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

    8.3 Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

    Skin protection

    Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

    Thermal hazards

    no data available

    SECTION 9: Physical and chemical properties and safety characteristics

    Physical state

    Pyridine is a clear colorless to light yellow liquid with a penetrating nauseating odor. Density 0.978 g / cm3. Flash point 68°F. Vapors are heavier than air. Toxic by ingestion and inhalation. Combustion produces toxic oxides of nitrogen.


    Colorless to yellow liquid.


    Sharp, nauseating

    Melting point/freezing point


    Boiling point or initial boiling point and boiling range



    Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F.

    Lower and upper explosion limit/flammability limit

    LOWER 1.8%; UPPER 12.4%

    Flash point


    Auto-ignition temperature

    900° F (USCG, 1999)

    Decomposition temperature

    no data available


    8.5 (0.2 molar soln in water)

    Kinematic viscosity

    no data available


    greater than or equal to 100 mg/mL at 70.7° F (NTP, 1992)

    Partition coefficient n-octanol/water

    log Kow = 0.65

    Vapour pressure

    18 mm Hg at 68° F ; 20 mm Hg at 77° F (NTP, 1992)

    Density and/or relative density

    1.05g/mLat 25°C(lit.)

    Relative vapour density

    2.72 (NTP, 1992) (Relative to Air)

    Particle characteristics

    no data available

    SECTION 10: Stability and reactivity

    10.1 Reactivity

    Decomposes on burning. This produces toxic fumes of nitrogen oxides and hydrogen cyanide. The substance is a weak base. Reacts violently with strong oxidants and strong acids.

    10.2 Chemical stability

    Mixtures with formamide + iodine + sulfur trioxide are storage hazards, releasing carbon dioxide & sulfuric acid.

    10.3 Possibility of hazardous reactions

    Pyridine is a flammable ... liquid.The vapour is heavier than air and may travel along the ground; distant ignition possible.PYRIDINE is a base. Reacts exothermically with acids. During preparation of a complex of pyridine with chromium trioxide, an acid, the proportion of chromium trioxide was increased. Heating from this acid-base reaction led to an explosion and fire [MCA Case History 1284 1967]. A 0.1% solution of pyridine (or other tertiary amine) in maleic anhydride at 185°C gives an exothermic decomposition with rapid evolution of gas [Chem Eng. News 42(8); 41 1964]. Mixing pyridine in equal molar portions with any of the following substances in a closed container caused the temperature and pressure to increase: chlorosulfonic acid, nitric acid (70%), oleum, sulfuric acid (96%), or propiolactone [NFPA 1991]. The combination of iodine, pyridine, sulfur trioxide, and formamide developed a gas over pressurization after several months. This arose from the slow formation of sulfuric acid from external water, or from dehydration of the formamide to hydrogen cyanide. Ethylene oxide and SO2 can react violently in pyridine solution with pressurization if ethylene oxide is in excess (Nolan, 1983, Case History 51).

    10.4 Conditions to avoid

    no data available

    10.5 Incompatible materials

    Pyridine reacts violently with chlorosulfonic acid, chromic acid, maleic anhydride, nitric acid, fuming sulfuric acid, perchromates, beta-propiolactone, silver perchlorate, & sulfuric acid.

    10.6 Hazardous decomposition products

    When pyridine is heated to decomposition, cyanide fumes are released.

    SECTION 11: Toxicological information

    Acute toxicity

    • Oral: LD50 Rat oral 1.58 g/kg
    • Inhalation: LC50 Rat inhalation 9000 ppm for 1 hr
    • Dermal: LD50 Guinea pig percutaneous 1.0 - 2.0 ml/kg

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available


    A3: Confirmed animal carcinogen with unknown relevance to humans.

    Reproductive toxicity

    no data available

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    SECTION 12: Ecological information

    12.1 Toxicity

    • Toxicity to fish: LC50 Pimephales promelas (fathead minnow) 106 mg/l/96 hr, flow-through bioassay with measured concentrations, 24.1 deg C, dissolved oxygen 7.4 mg/l, hardness 47.4 mg/l CaCO3, alkalinity 240 mg/l CaCO3, and pH 7.73.
    • Toxicity to daphnia and other aquatic invertebrates: no data available
    • Toxicity to algae: no data available
    • Toxicity to microorganisms: no data available

    12.2 Persistence and degradability

    Results of biodegradability screening tests for pyridine using sewage or activated sludge inocula give mixed results ranging from rapid to no degradation(1-5,7). Although biodegradability is improved in longer tests employing a more vigorous inocula, sometimes the same test gives disparate results(1-4,7). Variations in the particular sewage or activated sludge inoculum would affect test results. One investigator obtained results ranging from 97% degradation in 6 days to no degradation in 30 days in 6 different standard tests(1). After a preincubation step was added to one test in which no degradation was observed in 19 days, degradability increased to 91%(3). However the closed bottle test which employs only a drop of sewage effluent as an inoculum, registered no degradation even with a preincubation step(1,3). Tests that were designed to simulate biological treatment plants resulted in complete and rapid removal of pyridine(1,9). In one test that employed a soil suspension as an inoculum, 100% degradation was obtained in 66-170 days(6). When this test was repeated under anaerobic conditions, degradation was more rapid(6). Complete degradation was obtained in 32-66 days(6). When 2 micromoles/g of pyridine was incubated with a silt loam soil, 11.7% remained after 4 days and none remained after 8 days(8). The biodegradation rate constant for pyridine in water was 0.0033 - 0.018 per hour which corresponds to half-lives of 39-210 hours(10).

    12.3 Bioaccumulative potential

    The bioconcentration factor in guppies exposed to an unspecified concentration of pyridine over a 2-day incubation period was 88(1). According to a classification scheme(2), this BCF suggests the bioconcentration in aquatic organisms moderate.

    12.4 Mobility in soil

    The Koc of pyridine is estimated as 50(SRC), using a measured log Kow of 0.65(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that pyridine is expected to have high mobility in soil. The pKa of pyridine is 5.23(4), which indicates that pyridine will partially exist in the protonated form under acidic conditions and cations adsorb more strongly to soil surfaces than neutral molecules(SRC). The adsorption of pyridine to a basic subsoil (pH 8.15, 0.58% organic carbon) is negligible, while in an acidic subsoil (pH 4.85, O.24% organic carbon), the Freundlich adsorption constant was measured to be 5.78 and the slope 0.679(5). This suggests a cationic adsorption mechanism as pyridine is predominantly in its protonated form. Pyridine adsorbs to colloidal particles of sodium montmorillonite and kaolinite, a process which is attributed to cation exchange and is a function of pH(5). Adsorption is at a minimum at pH 1 and 11 and reaches a maximum at pH 4 for the montmorillonite and pH 5.5 for the kaolinite where the adsorption constants are 60 and 10, respectively(6).

    12.5 Other adverse effects

    no data available

    SECTION 13: Disposal considerations

    13.1 Disposal methods


    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    SECTION 14: Transport information

    14.1 UN Number

    ADR/RID: UN1282 (For reference only, please check.) IMDG: UN1282 (For reference only, please check.) IATA: UN1282 (For reference only, please check.)

    14.2 UN Proper Shipping Name

    ADR/RID: PYRIDINE (For reference only, please check.) IMDG: PYRIDINE (For reference only, please check.) IATA: PYRIDINE (For reference only, please check.)

    14.3 Transport hazard class(es)

    ADR/RID: 3 (For reference only, please check.) IMDG: 3 (For reference only, please check.) IATA: 3 (For reference only, please check.)

    14.4 Packing group, if applicable

    ADR/RID: II (For reference only, please check.) IMDG: II (For reference only, please check.) IATA: II (For reference only, please check.)

    14.5 Environmental hazards


    14.6 Special precautions for user

    no data available

    14.7 Transport in bulk according to IMO instruments

    no data available

    SECTION 15: Regulatory information

    15.1 Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    (2H5)pyridine (2H5)pyridine 7291-22-7 230-720-2
    European Inventory of Existing Commercial Chemical Substances (EINECS) Listed.
    EC Inventory Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Not Listed.
    China Catalog of Hazardous chemicals 2015 Not Listed.
    New Zealand Inventory of Chemicals (NZIoC) Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Not Listed.
    Vietnam National Chemical Inventory Not Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Listed.
    Korea Existing Chemicals List (KECL) Not Listed.

    SECTION 16: Other information

    Information on revision

    Creation Date July 15, 2019
    Revision Date July 15, 2019

    Abbreviations and acronyms

    • CAS: Chemical Abstracts Service
    • ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
    • RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
    • IMDG: International Maritime Dangerous Goods
    • IATA: International Air Transportation Association
    • TWA: Time Weighted Average
    • STEL: Short term exposure limit
    • LC50: Lethal Concentration 50%
    • LD50: Lethal Dose 50%
    • EC50: Effective Concentration 50%


    • IPCS - The International Chemical Safety Cards (ICSC), website:
    • HSDB - Hazardous Substances Data Bank, website:
    • IARC - International Agency for Research on Cancer, website:
    • eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website:
    • CAMEO Chemicals, website:
    • ChemIDplus, website:
    • ERG - Emergency Response Guidebook by U.S. Department of Transportation, website:
    • Germany GESTIS-database on hazard substance, website:
    • ECHA - European Chemicals Agency, website:
    Any questions regarding this SDS, Please send your inquiry to

    Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

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