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    Home > API > Antiallergic Drugs (Find 101 items)

    Antiallergic Drugs


    Inhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma. Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM). Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.[Cayman Chemical]

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    Promethazine is a first generation histamine H1 receptor antagonist (Ki = 2.6 nM) whose antihistamine activity has been reported in guinea pigs and mice at ED50 values of 0.43 and 5.9 mg/kg, respectively.Promethazine can penetrate the CNS, depressing central H1 receptor activity, which may relate to its sedative properties, and can also inhibit muscarinic acetylcholine receptors (Ki = 22 nM). Furthermore, 32 mg/kg promethazine demonstrates antiemetic effects in ferret models of motion sickness or chemotherapy-induced nausea.


    For the relief of symptoms of seasonal allergic rhinitis, perennial (non-seasonal) allergic rhinitis. Desloratidine is also used for the sympomatic treatment of pruritus and urticaria (hives) associated with chronic idiopathic urticaria.

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    An allergic reaction is an allergic reaction, which refers to tissue damage or physiological dysfunction caused by the body being stimulated by antigenic substances, and is an immunopathological injury process. Drugs for preventing and treating allergic diseases caused by various antigenic substances (such as bacteria, viruses, parasites, pollen, etc.) are anti-allergic drugs. According to the different mechanism of action, it can be divided into: antihistamine drugs, allergic reaction mediator release drugs, histamine desensitizers, leukotriene receptor antagonists, drugs that inhibit antigen-antibody reactions, and improve or control allergic symptoms Medicines, etc. The "Echemi Antiallergic Drugs" list mainly supplies APIs for such drugs.
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