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    Home > API > Antineoplastic Agents (Find 255 items)

    Antineoplastic Agents

    Resveratrol

    (501-36-0)
    1. Antifungal, antibacterial
    2. Resveratrol is a phytoalexin produced naturally by several plants with anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects
    3. Minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression.
    4. Raw material for Tamiflu; Oseltamivir
    5. Resveratrol can reduce blood fat and the incidence of coronary heart disease. Resveratrol have special protection for cardiovascular system. Adjust the ratio of low-density lipoprotein (LDL); and reducing platelet aggregation effects; anti-aging, is expected to become a natural drug prevent cancer for human.

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    Letrozole

    (112809-51-5)
    A nonsteroidal aromatase inhibitor structurally related to Fadrozole. Antineoplastic Pyrrole type aromatase inhibitor. Used to treat breast cancer.

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    Erlotinib Hydrochloride

    (183319-69-9)
    Erlotinib hydrochloride (CAS NO.183319-69-9) is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. Erlotinib hydrochloride is a small molecule reversible inhibitor of epidermal growth factor receptor tyrosine kinase, which is mainly used for the second or third line treatment of locally advanced or metastatic non-small cell lung cancer and the treatment of pancreatic cancer. HER-1 / EGFR tyrosine kinase inhibitor

    Doxorubicin Hydrochloride

    (25316-40-9)
    1. Used as an antineoplastic
    2. Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA. Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent.
    3. Antibacterial;DNA intercalant
    4. Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.
    5. Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumor agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.
    6. Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.[Cayman Chemical]

    Fulvestrant

    (129453-61-8)
    1. A novel steroidal estrogen antagonist reported to lack any partial agonist activity. Antineoplastic (hormonal).
    2. Antiestrogen

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    Gefitinib

    (184475-35-2)
    1. Gefitinib (Iressa, ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively.
    2. Gefitinib is an antineoplastic.

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    Imatinib Mesylate

    (220127-57-1)
    Imatinib intermediates Anti-tumor drugs. A tyrosine kinase inhibitor that can inhibit c-Kit, Bcr-Abl and PDGFR (IC50: 100nM).

    Paclitaxel

    (33069-62-4)
    1. Glucocorticoid, antiinflammatory
    2. An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.

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    Docetaxel (Anhydrous)

    (114977-28-5)
    Antineoplastic;binds to microtubules Anticancer drugs. Used for uterine cancer. Uses Anti-tumor botanicals for the treatment of metastatic breast cancer and non-small cell lung cancer. Docetaxel can be used to study antibiotics, cell biology, cell signaling, neuroscience, apoptosis and cell cycle. Docetaxel is also used to study hair loss caused by docetaxel chemotherapy, to prevent and treat non-small cell lung cancer in patients who are contraindicated with standard chemotherapy. Docetaxel has also been used to study the effects of hypoxia-inducible factor-1α and 2α in androgen-insensitive prostate cancer cells.

    Bortezomib

    (179324-69-7)
    It is used as a medicine to treat some refractory disease, for example relapsed multiple myeloma and mantle cell lymphoma. Bortezomib is the first proteasome inhibitor approved by the US FDA for multiple myeloma (a blood cancer). Reversible 26S proteasome inhibitor, a barrel-shaped polyprotein particle, exists in the nucleus and cytoplasm of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.

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    Antineoplastic agents are a class of drugs used to treat tumor diseases. In short, there are chemotherapy drugs and biological agents. At present, there are more than 80 kinds of antineoplastic agents common in the world, which can be roughly divided into the following 6 categories: cytotoxic drugs, hormone drugs, biological response modifiers, monoclonal antibody drugs, other drugs, auxiliary drugs and so on. The "Echemi Antineoplastic Agents" list mainly supplies APIs for such drugs.
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