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    Home > API > Inhibitor Drugs (Find 8 items)

    Inhibitor Drugs

    GW-501516

    (317318-70-0)
    An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream.A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPARγ. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells.

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    Afatinib

    (439081-18-2)
    BIBW 2992 is an anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity. Afatinib is an aminocrotonylamino-substituted quinazoline derivative used to treat cancers and diseases of the respiratory tract, lung, gastrointestinal tract, bile duct and gallbladder.

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    Sitagliptin phosphate monohydrate

    (654671-77-9)
    Sitagliptin phosphate is very effective in treating type 2 diabetes. As a new type of anti-diabetic drug, sitagliptin phosphate is blood sugar-dependent, has a moderate hypoglycemic effect, increases insulin secretion without hypoglycemia, effectively reduces hunger and other advantages, and has no nausea, vomiting, edema and increase Side effects such as body weight.

    Crizotinib

    (877399-52-5)
    PF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley Crizotinib is a small molecule tyrosine kinase inhibitor (TKI) that targets anaplastic lymphoma kinase (ALK), ROS1, and another oncogene receptor tyrosine kinase MET.

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    PD 0332991 HCl

    (827022-32-2)
    Palbociclib hydrochloride is a highly selective CDK4/6 inhibitor with IC50s of 11 nM and 16 nM, respectively.

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    Fingolimod hydrochloride

    (162359-56-0)
    A cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties. Fingolimod is a sphingosine-l-phosphate (S1PR) receptor modulator, which binds to the s1P receptor on the surface of lymphocytes after phosphorylation in the body, changes the migration of lymphocytes, and promotes cells to enter lymphatic tissues. Prevent it from leaving the lymphatic tissue and enter the graft, thereby preventing these cells from infiltrating the central nervous system (CNS), thereby achieving the effect of immunosuppression.

    Selumetinib

    (606143-52-6)
    It is a tight-binding, uncompetitive inhibitor of mitogen-activated protein kinase kinases (MEK) 1 and 2 currently in clinical development. The anticancer drug Selumetinib (Selumetinib, 1) was developed by the British company AstraZeneca for the treatment of advanced non-small cell lung cancer (NSCLC). Smeltinib mainly regulates the level of MEK, a key protein kinase in the Ras-Raf-MEK-ERK pathway, to inhibit melanoma with B-Raf-mutation and non-small cell lung cancer (NSCLC) with K-Ras mutation. The growth of a variety of tumors. Mainly used for the treatment of cholangiocarcinoma, colorectal cancer, NSCLC, etc. Simetinib is currently in a phase III clinical trial for the treatment of non-small cell lung cancer.

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    Inhibitors drugs are psychotropic drugs, and common ones include alcohol, opium, and barbiturates, which inhibit or reduce the transmission of nerve impulses in the central nervous system, thereby suppressing (slowing) mental and physical activity. "Inhibitor Drugs" on Echemi mainly supplies APIs for inhibitor drugs.
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