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Iridoid Derivatives

Catalpol

(2415-24-9)
The main function is to stimulate the production of adrenal cortex hormones, thereby increasing the production of hormones. Catalpol also has anti-inflammatory activity and has been shown to increase the production of androgens produced by the adrenal glands, which leads to increased muscle mass.

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Asperuloside

(14259-45-1)
Trifocin, needle-like crystals (acetone), soluble in water, methanol, ethanol, acetone, ethyl acetate, dioxane, pyridine, acetic acid, almost insoluble in ether, benzene, chloroform, etc. Asperuloside is an iridoid compound with a wide range of pharmacological effects such as antibacterial, antioxidant, antimutagenic, antitumor, anti-inflammatory and analgesic.

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Loganic acid

(22255-40-9)
Loganic acid is an iridoid isolated from cornelian cherry fruits. Loganic acid can modulate diet-induced atherosclerosis and redox status. Loganic acid has strong free radical scavenging activity and remarkable cyto-protective effect against heavy metal mediated toxicity[1][2].

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SHANZHISIDE METHYL ESTER

(64421-28-9)
Shanzhiside methy lester is isolated from L. rotata. Shanzhiside methyl ester is a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist and has the ability to induce anti-allodynic tolerance[1].

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Gardenoside

(24512-62-7)
Gardenoside is a natural compound found in Gardenia fruits, with hepatoprotective properties. Gardenoside suppresses the pain of chronic constriction injury by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis[1][2].

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Barlerin

(57420-46-9)
8-O-Acetyl shanzhiside methyl ester (ND01) is an iridoid glucoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant in Xi-zang. 8-O-Acetyl shanzhiside methyl ester could inhibt NF-κB.

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Shanzhiside

(29836-27-9)
Shanziside is a iridoid glucoside isolated from Phlomis tuberosa L[1].

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sesamoside

(117479-87-5)
Flax glycosides have anti-inflammatory, heat-clearing and detoxifying effects.

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8-O-Acetylharpagide

(6926-14-3)
8-O-Acetylharpagide is an iridoid isolated from Ajuga reptans with antitumoral, antiviral, antibacterial, and anti-inflammatory activities. 8-O-Acetylharpagide also has a biological activity on isolated smooth muscle preparations from guinea pig[1][2].

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Iridoids are derivatives of monoterpenes and occur usually, but not invariably, as glycosides. Iridoids and their glycoside derivatives are commonly found in a number of species of this genus including H. diffusa, H. hedyotidea, H. chrysotricha and H. corymbosa.

Frequently Asked Questions

What are Iridoid Derivatives?

Iridoid derivatives are a class of naturally occurring monoterpenoid compounds commonly found in various medicinal plants. They are characterized by a cyclopentane ring fused to a six-membered oxygen heterocycle and are known for their diverse biological activities, including anti-inflammatory, antioxidant, hepatoprotective, and neuroprotective effects. These compounds serve as key phytochemicals in herbal medicine and pharmaceutical research.

What are the common applications of Iridoid Derivatives in the pharmaceutical industry?

Iridoid derivatives are widely used in the pharmaceutical industry due to their therapeutic potential. Common applications include:1. Development of anti-inflammatory and analgesic drugs.2. Formulation of hepatoprotective agents for liver health.3. Use in neuroprotective therapies for conditions like Alzheimer’s disease.4. Incorporation into natural health products and dietary supplements.Their bioactive properties make them valuable in both traditional and modern medicine formulations.

How are Iridoid Derivatives extracted and purified for commercial use?

Iridoid derivatives are typically extracted from plant sources such as Valeriana officinalis, Gardenia jasminoides, and Eucommia ulmoides using solvent extraction methods (e.g., ethanol or methanol). The crude extract is then purified through techniques like column chromatography, preparative HPLC, or crystallization to obtain high-purity iridoid compounds suitable for pharmaceutical or nutraceutical applications. Quality control during extraction ensures consistent potency and safety.

What factors should buyers consider when sourcing Iridoid Derivatives from suppliers?

When sourcing iridoid derivatives, buyers should evaluate:1. Supplier compliance with GMP and ISO standards.2. Analytical documentation including HPLC or NMR data confirming compound identity and purity.3. Traceability of raw materials to ensure sustainable and ethical sourcing.4. Stability and shelf-life data of the final product.5. Technical support and regulatory assistance for international markets.Selecting a reputable supplier enhances product reliability and regulatory compliance.

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