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Home > Natural Products > Lignans (Find 184 items)

Lignans

Rosmarinic Acid

(20283-92-5)
1. Rosmarinic Acid is a phenolic compound with antioxidant and anti-inflammatory activity. Rosmarinic Acid has been shown to inhibit againts peroxidative damage to biomembranes. Rosmarinic Acid also suppresses endotoxin-induced activation of complement and concomitant prostacyclin biosynthesis.
2. An activator of GPR35.

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Honokiol

(35354-74-6)
Honokiol is a small-molecule polyphenol isolated from the genus Magnolia. Recent studies show that Honokiol displays antiangiogenic, antiinflammatory, and antitumor properties in preclinical models, w ithout appreciable toxicity. Honokiol has been shown to inhibit the bone metastatic growth of human prostate cancer cells.

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ChicoricAcid

(6537-80-0)
Chicoric Acid is an effective inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. Also a class of cannabinomimetics with CB2 receptor-dependent and independent

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Gomisin A

(58546-54-6)
Schisandrol B is one of its major active constituents of traditional hepato-protective Chinese medicine, Schisandra sphenanthera.IC50 value:Target:in vitro: SolB pretreatment significantly attenuated the increases in alanine aminotransferase and aspartate aminotransferase activity, and prevented elevated hepatic malondialdehyde formation and the depletion of mitochondrial glutathione (GSH) in a dose-dependent manner. SolB also dramatically altered APAP metabolic activation by inhibiting

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magnolin

(31008-18-1)
Magnolin, a major component of Magnolia flos (Shin-Yi), inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively.

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ASARININ

(133-04-0)
(-)-Asarinin is a extract lignan from Zanthoxylum armatum, mainly produced in roots of this herb[1].

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PHYLLANTHIN

(10351-88-9)
Phyllanthin is a major bioactive lignan component of Phyllanthus amarus. Phyllanthin exhibits high antioxidative and hepatoprotective properties[1].

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HYPOPHYLLANTHIN

(33676-00-5)
Hypophyllanthin is a major lignan in Phyllanthus spp, with strong anti-inflammatory activity. Hypophyllanthin directly inhibits P-glycoprotein (P-gp) activity and did not interfere with multidrug resistance protein 2 (MRP2) activity[1][2].

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Lignans is a type of natural component formed by the bimolecular polymerization of phenylpropanin. There are four types of monomers that make up lignans: cinnamic acid and occasionally cinnamaldehyde. Cinnamyl alcohol. Acrylic benzene. Allylbenzene. The substance exists in plants and belongs to a phytoestrogen, which has the effect of scavenging free radicals in the body and anti-oxidation.
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