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Brevilin A

This naturally occurring sesquiterpenoid (FW = 346.40 g/mol; CAS 16503- 32-5) from the volatile oils of the plant Centipeda minima inhibits (IC50 = 10 μg/mL) STAT3 phosphorylation in the Jak/STAT signal transduction pathway of A549R cells. Brevilin A showed high specificity on Janus Kinase activity and following STAT3 signaling without directly affecting some other signals, including p65, AKT and GSK-3β phosphorylation, as well as Src kinase activity. Brevilin A is also an antibiotic with activ

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Stachybotrylactam is an unusual spirodihydrobenzofuranlactam mycotoxin isolated from a Stachybotrys sp. that has immunosuppressant and weak HIV protease activity. Members of this structural class show diverse activity including antiviral, endothelin and pancreatic cholesterase inhibition.


Spathulenol is isolated from Psidium guineense Sw, and has antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. Spathulenol shows a high antioxidant activity with an IC50 of 85.60 μg/mL in the DPPH system[1].
The sesquicarbonyl group (sesquiterpene) refers to a natural alkyl compound containing 15 carbon atoms in the molecule and contains three isoprene units. It has various stacking structures such as chain and ring. Uncle sesqui is mostly liquid and mainly exists in the volatile oil of plants. Oxygen derivatives such as alcohols, ketones and lactones are also widely present in volatile oils.
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