Ethyl acetate layer, steamed dry, methanol dissolved, why not extract directly with methanol?IntersectionIntersection

The polarity of methanol is relatively large, and the extracted things are miscellaneous.A large amount of extraction is rarely used for methanol because methanol is more toxic, but the solubility of methanol for organic matter is better, so ~~~~

The extraction of ethyl acetate is definitely not the same as the extraction of methanol ~ at least not the same in polarity ~
Ethyl acetate kicking the ball is generally the same after the methanol dissolves ~Large, so it is okay even if it cannot be dissolved

The dissolving performance of methanol is better, which can dissolve many substances that can not be extracted by many ethyl acetate.Therefore, in order to extract impurities as little as possible with ethyl acetate to ensure purity.

First of all, methanol polarity is larger than ethyl acetate.Extraction with water, ethyl acetate extract, and the concentrated steaming process is also a rough process.If you use a methanol to extract a lot of impurities, it will affect the judgment of HPLC results, and it will pollute the chromatography column.If you want to extract it directly with methanol, you can use a 1ml needle to draw HPLC through the filter film, so that the chromatography column is better.

Ethyl acetate is neutral. The extraction of ethyl acetate is generally to go out to go out of the sugar substances with large polarity.

First of all, the samples that are directly in the sample with methanol are dirty. If it is purified, it is easy to pollute the chromaton pillar.]

Acetate is used for dehydration. The water lifting is first cheap. Monol may not be cheap, and according to the different purposes, the extraction solvent must be tested. There is a process of exploration.Research.The second problem: there is another "re -extraction" process of methanol dissolution ... The things written in the literature are very "classic", such as water used, which may be written directly, but what is used in actual experiments useLevel water is unknown, this is also one of the "scientific confidentiality" methods