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What is the meaning of the word "Ligandable" in "ligandable proteome"?
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Kieren Reeves
What is the meaning of the word "Ligandable" in "ligandable proteome"?
Ligand is borrowed from Latin ligandus, imperative verb tense of ligo (“bind, bandage, unite”), From Proto-Indo-European *leyǵ- (“to bind”).
You can find it in many words in English, French, Spanish, i.e. Liaison which means "to link, to associate"
In chemistry, it means: An ion, molecule, or functional group that binds to another chemical entity to form a larger complex.
Ligand is a latin scientific word which means "to link, to associate, to bind together" so you can just substitute the text books for one of those words. European scientists often know 500 or 1000 latin and greek word constructions like that. Words like Astro, Geo, Bio, logos, Con, anti, which are used commonly in science.
Ligand is borrowed from Latin ligandus, imperative verb tense of ligo (“bind, bandage, unite”), From Proto-Indo-European *leyǵ- (“to bind”).
You can find it in many words in English, French, Spanish, i.e. Liaison which means "to link, to associate"
In chemistry, it means: An ion, molecule, or functional group that binds to another chemical entity to form a larger complex.
Ligand is a latin scientific word which means "to link, to associate, to bind together" so you can just substitute the text books for one of those words. European scientists often know 500 or 1000 latin and greek word constructions like that. Words like Astro, Geo, Bio, logos, Con, anti, which are used commonly in science.
So, in conclusion, "ligandable proteins" means that proteins have an ability to link, right?More
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In biochemistry, ligand is usually taken to mean a substance which binds to a larger molecule such as an enzyme or other protein, thereby forming a larger complex. The study of ligand binding has been important for pharmaceuticals, particularly in ligand-based drug design.
In recent years, the term druggability has increasingly been adopted to describe the ability of a protein target to bind small molecules with high affinity; however, we believe the term ‘ligandability’ is more appropriate for this purpose. Although ligandability is a requirement for finding drugs for a particular target, it is not a guarantee that such ligands will make good drugs.
So, ligandable usually refers to the capability of a molecular target of drug design to bind small molecules. A ligandable proteome would then be a set of proteins capable of binding small molecules.
In biochemistry, ligand is usually taken to mean a substance which binds to a larger molecule such as an enzyme or other protein, thereby forming a larger complex. The study of ligand binding has been important for pharmaceuticals, particularly in ligand-based drug design.
In recent years, the term druggability has increasingly been adopted to describe the ability of a protein target to bind small molecules with high affinity; however, we believe the term ‘ligandability’ is more appropriate for this purpose. Although ligandability is a requirement for finding drugs for a particular target, it is not a guarantee that such ligands will make good drugs.
So, ligandable usually refers to the capability of a molecular target of drug design to bind small molecules. A ligandable proteome would then be a set of proteins capable of binding small molecules.
Ligand is borrowed from Latin ligandus, imperative verb tense of ligo (“bind, bandage, unite”), From Proto-Indo-European *leyǵ- (“to bind”).
You can find it in many words in English, French, Spanish, i.e. Liaison which means "to link, to associate"
In chemistry, it means: An ion, molecule, or functional group that binds to another chemical entity to form a larger complex.
Ligand is a latin scientific word which means "to link, to associate, to bind together" so you can just substitute the text books for one of those words. European scientists often know 500 or 1000 latin and greek word constructions like that. Words like Astro, Geo, Bio, logos, Con, anti, which are used commonly in science.
https://www.google.com/search?q=rely+etymology&oq=rely+etymology&aqs=chrome..69i57j0.4031j0j9&sourceid=chrome&ie=UTF-8
Ligand is borrowed from Latin ligandus, imperative verb tense of ligo (“bind, bandage, unite”), From Proto-Indo-European *leyǵ- (“to bind”).
You can find it in many words in English, French, Spanish, i.e. Liaison which means "to link, to associate"
In chemistry, it means: An ion, molecule, or functional group that binds to another chemical entity to form a larger complex.
Ligand is a latin scientific word which means "to link, to associate, to bind together" so you can just substitute the text books for one of those words. European scientists often know 500 or 1000 latin and greek word constructions like that. Words like Astro, Geo, Bio, logos, Con, anti, which are used commonly in science.
https://www.google.com/search?q=rely+etymology&oq=rely+etymology&aqs=chrome..69i57j0.4031j0j9&sourceid=chrome&ie=UTF-8
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In biochemistry, ligand is usually taken to mean a substance which binds to a larger molecule such as an enzyme or other protein, thereby forming a larger complex. The study of ligand binding has been important for pharmaceuticals, particularly in ligand-based drug design.
The term ligandability (and hence ligandable) seems to have come into significant use with a paper by Edfeldt, Folmer, and Breeze in which they say:
So, ligandable usually refers to the capability of a molecular target of drug design to bind small molecules. A ligandable proteome would then be a set of proteins capable of binding small molecules.
In biochemistry, ligand is usually taken to mean a substance which binds to a larger molecule such as an enzyme or other protein, thereby forming a larger complex. The study of ligand binding has been important for pharmaceuticals, particularly in ligand-based drug design.
The term ligandability (and hence ligandable) seems to have come into significant use with a paper by Edfeldt, Folmer, and Breeze in which they say:
So, ligandable usually refers to the capability of a molecular target of drug design to bind small molecules. A ligandable proteome would then be a set of proteins capable of binding small molecules.
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