Neonatal hepatosplenomegaly refers to clinical neonatal hepatomegaly and spleen enlargement. That is, the size of the liver and spleen exceeds the normal range (the upper limit of the normal neonatal liver is generally in the 4th intercostal space on the right clavicle midline, and the lower limit is generally 1 to 2 cm below the right costal margin, and it is easier to touch under the xiphoid process, about 2 cm. The spleen cannot be touched or does not exceed 1 cm below the costal margin on the left clavicle midline, and the texture is soft.). In the neonatal period, hepatosplenomegaly is a common clinical symptom, and the cause should be found as soon as possible to distinguish whether it is a benign self-limiting disease or a malignant lesion. There are many diseases that cause hepatosplenomegaly, and diagnosis and treatment are also more difficult.