This disease is also called pancreatic subcutaneous nodular fat necrosis. Its clinical features are repeated batches of red, painful subcutaneous nodules with a diameter of 0.5 to 5 cm. The lesions first occur on the calves and may later spread to the skin of the whole body. Some nodules may contain sterile viscous substances after the softening period. When the lesions appear, they may be accompanied by paroxysmal abdominal pain, polyarthritis (or arthralgia), fever and eosinophilia. The lesions spontaneously retract without epidermal atrophy. Hansemann (1889) first discovered that nodular subcutaneous fat necrosis was related to pancreatic disease. Blauvelt (1946) noticed that nodular lesions on the calves may occur in acute pancreatitis.