Nodular panniculitis (NP), also known as Weber-Christian disease or relapsing nodular nonsuppurative febrile panniculitis, is a disease characterized by recurrent inflammatory nodules or plaques in the subcutaneous fat layer, accompanied by systemic symptoms such as fever. The disease was first reported by Pfeifer in 1882, Weber described the recurrent and non-suppurative characteristics of the disease in 1952, and Christian emphasized the fever in 1928. The disease is not rare in clinical practice, because of its diverse clinical manifestations. NP can occur at any age, but it is more common in women aged 30 to 50, with a female to male ratio of about 2.5:1. It is not easy to recognize and often leads to misdiagnosis.