Bactericidal cephalosporin antibiotics work by inhibiting bacterial cell wall synthesis. It is effective against a broad spectrum of Gram-positive and Gram-negative bacteria and can tolerate most beta-lactamases. It is effective against strains resistant to gentamicin and other aminoglycosides. When used in combination with aminoglycoside antibiotics, the efficacy is at least additive, and it has a significant synergistic effect on some strains.

Bactericidal cephalosporin antibiotics work by inhibiting bacterial cell wall synthesis. Effective against a broad spectrum of Gram-positive and Gram-negative bacteria, resistant to most β-lactamases, and sensitive to many pathogenic strains and pathogenic strains associated with hospital-acquired infections, including strains resistant to gentamicin and other aminoglycosides. Highly stable to β-lactamases produced by most clinically important Gram-positive and Gram-negative bacteria, effective against many strains resistant to ampicillin and cephalothin. When used in combination with aminoglycoside antibiotics, the efficacy is at least additive, with significant synergistic effects against certain strains.

This product is a first-generation cephalosporin, which has good antibacterial effect on some strains of Gram-positive cocci such as non-penicillinase-producing and penicillinase-producing Staphylococcus aureus, coagulase-negative Staphylococcus, group A hemolytic Streptococcus, Streptococcus pneumoniae and viridans Streptococcus. Anaerobic Gram-positive bacteria are mostly sensitive to this product, and Bacteroides fragilis is resistant to this product. Methicillin-resistant Staphylococci and Enterococci are resistant to this product. The effect of this product on Gram-positive and Gram-negative bacteria is similar to that of cephalexin. This product has a certain effect on Neisseria gonorrhoeae, and is also active against enzyme-producing Neisseria gonorrhoeae; its activity against Haemophilus influenzae is poor.

This product is a third-generation cephalosporin with a broad-spectrum antibacterial effect. It is a third-generation cephalosporin antibiotic produced against a variety of Gram-positive and Gram-negative bacteria. It has strong activity against Enterobacteriaceae. The MIC90 for Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Citrobacter fluorescens, indole-positive Proteus, Providencia and Serratia is between 0.12 and 0.25 mg/L. Enterobacter cloacae, Acinetobacter and Pseudomonas aeruginosa are poorly sensitive to this product. It has a strong antibacterial effect on Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis, and also has a good effect on hemolytic streptococci and pneumococci. The MIC for Staphylococcus aureus is 2 to 4 mg/L. Methicillin-resistant Staphylococci and enterococci are resistant to this product. Most Bacteroides fragilis are resistant to this product.

Second-generation cephalosporin antibiotics are rapidly hydrolyzed into cefuroxime after entering the body. They have strong antibacterial effects on most Gram-positive cocci, good effects on diphtheria and Gram-positive anaerobic bacteria, strong activity against Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae and Haemophilus influenzae, sensitive to Salmonella typhi, Shigella, Neisseria gonorrhoeae and Neisseria meningitidis, poor antibacterial effects on Bacteroides fragilis, and resistant to Serratia, Alcaligenes, Acinetobacter and Pseudomonas aeruginosa. Its mechanism of action is to bind to penicillin-binding proteins (PBPs) on the bacterial cell membrane, inhibit the synthesis of bacterial septa and cell walls, and ultimately cause bacterial dissolution and death.