This product is a semi-synthetic aminoglycoside antibiotic. It has strong antibacterial activity against aerobic Gram-negative bacteria, and its antibacterial spectrum is similar to that of gentamicin. It has good antibacterial effects on Escherichia coli, Pseudomonas aeruginosa, indole-negative and -positive Proteus, Klebsiella, Acinetobacter, Citrobacter, and some strains of Serratia and Enterobacter. It also has good antibacterial effects on Mycobacterium tuberculosis, atypical mycobacteria and Staphylococcus aureus (enzyme-producing and non-enzyme-producing strains). Other Gram-positive bacteria (including fecal streptococci), anaerobic bacteria, Rickettsia, fungi and viruses are not sensitive to this product. This product is stable to aminoglycoside acetyltransferase AAC (3), so it can produce this enzyme. Strains resistant to kanamycin, gentamicin, tobramycin and sisomicin are sensitive to this product. This product can often achieve synergistic effects when used in combination with beta-lactams. The mechanism of action of this product is to bind to the 30S subunit of the bacterial ribosome and inhibit the synthesis of bacterial proteins. Animal test data indicate that this product has lower ototoxicity than gentamicin and tobramycin, and lower nephrotoxicity than gentamicin.

This product is a semi-synthetic aminoglycoside antibiotic. It has strong antibacterial activity against aerobic Gram-negative bacilli, and has good antibacterial effects on Escherichia coli, Pseudomonas aeruginosa, indole-negative and -positive Proteus, Klebsiella, Acinetobacter, Citrobacter, and some strains of Serratia and Enterobacter. It also has good antibacterial effects on Mycobacterium tuberculosis, atypical mycobacteria and Staphylococcus aureus (enzyme-producing and non-enzyme-producing strains). Other Gram-positive bacteria (including Streptococcus faecalis), anaerobic bacteria, Rickettsia, fungi and viruses are not sensitive to this product. This product is stable to aminoglycoside acetyltransferase AAC (3), so it can produce this enzyme. Strains resistant to kanamycin, gentamicin, tobramycin and sisomicin are sensitive to this product. This product can often achieve synergistic effects when used in combination with beta-lactams. The mechanism of action of this product is to bind to the 30S subunit of the bacterial ribosome and inhibit the synthesis of bacterial proteins. Animal test data indicate that this product has lower ototoxicity than gentamicin and tobramycin, and lower nephrotoxicity than gentamicin.

This product belongs to the macrolide antibiotics, which is the ethyl succinate of erythromycin. It is more stable than erythromycin in gastric acid. It has antibacterial activity against Staphylococcus (except methicillin-resistant strains), various groups of streptococci and Gram-positive bacilli. Neisseria, Haemophilus influenzae, Bordetella pertussis, etc. are also sensitive to this product. This product also has antibacterial effects on various anaerobic bacteria except Bacteroides fragilis and Fusobacterium. It also has inhibitory effects on Legionella, Campylobacter fetus, some spirochetes, Mycoplasma pneumoniae, Rickettsia and Chlamydia. This product is an antibacterial agent, but it also has a bactericidal effect on some bacteria at high concentrations. This product can penetrate the bacterial cell membrane and form a reversible bond with the 50S subunit of the bacterial ribosome near the donor site (P site), blocking the transfer RNA (t-RNA) from binding to the P site, and also blocking the displacement of the polypeptide chain from the acceptor site (A site) to the P site, thereby inhibiting bacterial protein synthesis.

It achieves bactericidal effect by inhibiting the synthesis of bacterial cell wall. It has bactericidal effect on a wide range of common clinical bacteria and can resist hydrolysis by a variety of beta-lactamases. Bacteria sensitive to this product include Gram-positive bacteria, Gram-negative bacteria and some anaerobic bacteria.

It achieves bactericidal effect by inhibiting the synthesis of bacterial cell wall. It has bactericidal effect on a wide range of common clinical bacteria and can resist hydrolysis by multiple beta-lactamases. Bacteria sensitive to this product include Gram-positive bacteria: Staphylococcus aureus (including strains that produce and do not produce penicillinase), Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, and Streptococcus agalactiae. Gram-negative bacteria: Escherichia coli, Klebsiella, Enterobacter, Citrobacter, Haemophilus influenzae (including strains that produce and do not produce beta-lactamase), Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia, Serratia, Salmonella, Shigella. Pseudomonas aeruginosa and some other Pseudomonas, some strains of calcoacetic Acinetobacter. Neisseria gonorrhoeae (including strains that produce and do not produce penicillinase), Neisseria meningitidis, Bordetella pertussis. Anaerobic bacteria: Peptococcus, Peptostreptococcus, Veillonella, Clostridium, Eubacterium, Lactobacillus, Fusobacterium, various strains of Bacillus fragilis, and other Bacteroides.