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Tianjin Pacific Pharmaceutical Co., Ltd.
  • Founded in:

    1994-08-08
  • Country:

    China China
  • Address:

    Economic Development Zone, Xiqing District, Tianjin
  • Tax NO.:

    91120111600584134N
  • Registered Funds:

    133.19 million yuan
  • Website:

  • Email:

Related Drugs
Halcinonide Cream
Halcinonide (clofosinolone, halcinonide). Chemical name: 16,17-[(1-methylethylidene)bis(oxy)-11-hydroxy-21-chloro-9-fluoropregnane-4-ene-3,20-dione.
Name Description Content CAS NO. Registered Holders
Halcinonide

This product is a highly effective fluorinated and chlorinated corticosteroid with anti-inflammatory, antipruritic and vasoconstrictive effects. Its anti-inflammatory and antipruritic mechanism is to increase the responsiveness of b receptors to catecholamine, increase the production of cAMP by activating adenylate cyclase, and inhibit phosphoethylesterase to reduce the destruction of cAMP, resulting in an increase in the concentration of cAMP in cells and inhibiting the release of histamine. This product has a similar effect as dexamethasone in inhibiting the proliferation of granulomas in rats and mice; it has a significant weight-reducing effect on the thymus and spleen; it reduces the number of T lymphocytes, monocytes, and eosinophils, inhibits lymphocyte proliferation and cytokine production, inhibits macrophage differentiation and phagocytic activity, inhibits neutrophil adhesion, reduces vascular endothelial cell permeability, inhibits fibroblast proliferation and collagen synthesis, and inhibits sebaceous gland cell activity; it has an anti-mitotic effect, reduces PNA transcription, thereby reducing DNA synthesis, and also affects DNA repair, causing the epidermis to become thinner, especially having the greatest effect on collagen synthesis; it activates lytic gene expression and induces nuclear DNA lysis in lymphocytes to directly kill lymphocytes by binding to the cytoplasmic corticosteroid receptors.

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This product is a highly effective fluorinated and chlorinated corticosteroid with anti-inflammatory, antipruritic and vasoconstrictive effects. Its anti-inflammatory and antipruritic mechanism is to increase the responsiveness of b receptors to catecholamine, increase the production of cAMP by activating adenylate cyclase, and inhibit phosphoethylesterase to reduce the destruction of cAMP, resulting in an increase in the concentration of cAMP in cells and inhibiting the release of histamine. This product has a similar effect as dexamethasone in inhibiting the proliferation of granulomas in rats and mice; it has a significant weight-reducing effect on the thymus and spleen; it reduces the number of T lymphocytes, monocytes, and eosinophils, inhibits lymphocyte proliferation and cytokine production, inhibits macrophage differentiation and phagocytic activity, inhibits neutrophil adhesion, reduces vascular endothelial cell permeability, inhibits fibroblast proliferation and collagen synthesis, and inhibits sebaceous gland cell activity; it has an anti-mitotic effect, reduces PNA transcription, thereby reducing DNA synthesis, and also affects DNA repair, causing the epidermis to become thinner, especially having the greatest effect on collagen synthesis; it activates lytic gene expression and induces nuclear DNA lysis in lymphocytes to directly kill lymphocytes by binding to the cytoplasmic corticosteroid receptors.

3093-35-4 9
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