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Tetracycline antibiotics. This product is a broad-spectrum antibacterial agent with bactericidal effects at high concentrations. Many Rickettsia, Mycoplasma, Chlamydia, atypical mycobacteria, and spirochetes are also sensitive to this product. This product is more effective against Gram-positive bacteria than Gram-negative bacteria, but Enterococcus is resistant to it. Others such as Actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, and Yersinia are sensitive to this product. This product has certain antibacterial activity against Neisseria gonorrhoeae, but penicillin-resistant Neisseria gonorrhoeae is also resistant to doxycycline. Due to the widespread use of tetracyclines over the years, common clinical pathogens have become seriously resistant to this product, including Gram-positive bacteria such as Staphylococcus and most Gram-negative bacilli. There is cross-resistance between this product and different varieties of tetracycline antibiotics. The mechanism of action of this product is that the drug can specifically bind to the A position of the bacterial ribosome 30S subunit, inhibiting the growth of the peptide chain and affecting the synthesis of bacterial protein. Animal experiments have confirmed that this product is teratogenic. In vitro tests have shown that this product may be mutagenic at a certain concentration.

Colistin mainly acts on the bacterial cell membrane, causing important substances in the cell to leak out, and secondly affects the functions of the nucleoplasm and ribosomes. It is a slow-acting bactericidal agent. Escherichia coli, Klebsiella, and Enterobacter are sensitive to this product, and the antibacterial activity against Pseudomonas aeruginosa varies greatly. Acinetobacter, Salmonella, Shigella, Haemophilus influenzae, Bordetella pertussis, and Legionella pneumophila are usually sensitive. Vibrio cholerae may be sensitive, but Vibrio el Tor is resistant. Serratia, Neisseria meningitidis, Neisseria gonorrhoeae, Proteus, and Brucella are all resistant. Bacteroides fragilis is resistant, while other Bacteroides and Eubacterium are very sensitive. All Gram-positive bacteria are resistant to colistin, and this product is a narrow-spectrum antibiotic.

Not described in detail