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No specific pharmacological action is mentioned

It belongs to the 14-membered macrolide antibiotics. It inhibits protein synthesis by hindering the association of the 50S subunit of the nucleoprotein and producing an antibacterial effect. It has a slightly better antibacterial effect on Gram-positive bacteria such as Streptococcus, Pneumococcus, and Staphylococcus than erythromycin, and has certain antibacterial activity against induced erythromycin-resistant strains. Clarithromycin and its metabolites have enhanced antibacterial effects on influenza bacilli, have certain effects on gonococci, Listeria, and Campylobacter jejuni, and have stronger effects on Legionella pneumophila, Mycoplasma pneumoniae, Chlamydia trachomatis, Ureaplasma urealyticum, etc. than erythromycin, with MIC90 of about 0.008-0.12 mg/L. In addition, it has certain activity against Borrelia burgdorferi, Mycobacterium avium, Toxoplasma gondii, etc., which are mostly better than other varieties. It has a strong antibacterial effect on anaerobic cocci, and its effect on Bacteroides fragilis is better than erythromycin. The antibiotic after-effect on Staphylococcus aureus, Streptococcus pyogenes, and influenza bacilli is significantly stronger than erythromycin. It also has an inhibitory effect on some Gram-negative bacteria such as Haemophilus influenzae, Bordetella pertussis, Gonorrhea, Legionella pneumophila and some anaerobic bacteria such as Bacteroides fragilis, Streptococcus peptostreptococcus, Propionibacterium acnes, etc. It also has an inhibitory effect on mycoplasma. There is cross-resistance between it and erythromycin.

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