Aminoglycoside antibiotics have good antibacterial effects on various Gram-negative and Gram-positive bacteria. The mechanism of action is to bind to the 30S subunit of the bacterial ribosome and inhibit the synthesis of bacterial proteins. In recent years, the number of Gram-negative bacteria resistant to gentamicin has increased significantly.

This product is an aminoglycoside antibiotic. It has good antibacterial effects on various Gram-negative and Gram-positive bacteria, and has good effects on various Enterobacteriaceae such as Escherichia coli, Klebsiella, Proteus, Salmonella, Shigella, Enterobacter, Serratia and Pseudomonas aeruginosa. Neisseria and Haemophilus influenzae are moderately sensitive to this product. It also has a certain effect on Brucella, Yersinia pestis, Acinetobacter and Campylobacter fetus. It has a good antibacterial effect on about 80% of methicillin-sensitive strains of Staphylococcus (including Staphylococcus aureus and coagulase-negative Staphylococci), but most methicillin-resistant strains are resistant to this product. It has a poor effect on Streptococcus and Streptococcus pneumoniae, and Enterococcus is mostly resistant to this product. When this product is used in combination with β-lactams, most of them can obtain a synergistic antibacterial effect. The mechanism of action of this product is to bind to the 30S subunit of the bacterial ribosome and inhibit the synthesis of bacterial proteins. In recent years, the number of Gram-negative bacteria resistant to gentamicin has increased significantly.

It has central and peripheral antitussive effects, and its antitussive effect is about 1/3 of that of codeine. In addition to having a direct inhibitory effect on the respiratory center of the medulla oblongata, it also has a mild atropine-like effect. It can relax spasmodic bronchial smooth muscles and reduce airway resistance.

It can directly stimulate adrenaline receptors, and can also indirectly stimulate adrenaline receptors by prompting adrenaline nerve endings to release norepinephrine. It has a stimulating effect on both alpha and beta receptors. It can dilate bronchi and constrict local blood vessels, and its action time is longer; it strengthens myocardial contractility, increases cardiac output, and makes venous return to the heart sufficient; it has a stronger central nervous system stimulating effect than adrenaline.

It has ① antihistamine effect, which can compete with histamine released from tissues for H1 receptors on effector cells, thereby stopping allergic reactions; ② at the same time, it inhibits central nervous system activity and causes sedative and hypnotic effects; ③ it enhances the effect of antitussive drugs.