As a histamine H1 receptor antagonist, this product can counteract the capillary dilation caused by allergic reactions, reduce the permeability of capillaries, and relieve wheezing caused by bronchial smooth muscle contraction. This product has a long-lasting antihistamine effect and also has a significant central inhibitory effect, which can increase the effects of anesthetics, analgesics, hypnotics and local anesthetics. This product is mainly metabolized in the liver.

It relaxes vascular smooth muscle, releases nitric oxide (NO) through metabolism to produce isosorbide mononitrate, activates guanylate cyclase, and increases cyclic guanosine monophosphate (cGMP) in smooth muscle cells, thereby relaxing vascular smooth muscle, dilating peripheral arteries and veins, reducing the amount of blood returning to the heart, lowering left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (preload), lowering peripheral vascular resistance, systolic arterial pressure and mean arterial pressure (afterload), and dilating coronary arteries to increase coronary perfusion, reduce myocardial oxygen consumption, increase oxygen supply, and relieve angina pectoris.

It relaxes vascular smooth muscle, releases nitric oxide (NO) through metabolism to generate isosorbide mononitrate, activates guanylate cyclase, and increases cyclic guanosine monophosphate (cGMP) in smooth muscle cells, thereby relaxing vascular smooth muscle, dilating peripheral arteries and veins, reducing myocardial oxygen consumption, increasing oxygen supply, and relieving angina pectoris.

Activation inhibits the release of pain transmitters from the lateral cord, leading to hyperactivation of intrinsic factor, which binds to the U subtype opioid receptors and inhibits serotonin and norepinephrine, thereby eliminating the pain response.

It has antibacterial effects on non-enzyme-producing Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Proteus mirabilis, Klebsiella, Salmonella, Proteus, Morganella, Shigella and other Enterobacteriaceae, Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Staphylococcus aureus; it also has good antimicrobial activity against Chlamydia trachomatis, Nocardia asteroides, protozoa, Toxoplasma gondii, etc. The mechanism of action is to interfere with the function of synthetic folate reductase, so that the folate metabolism of bacteria is doubly blocked. The synergistic antibacterial effect is stronger than that of a single drug, and the number of strains resistant to it is reduced.