Extract from the above information

1. It has a positive inotropic effect on the myocardium, mainly acting on β1 receptors, and has relatively little effect on β2 and α receptors. 2. It can directly excite cardiac β1 receptors to enhance myocardial contraction and increase stroke volume, thereby increasing cardiac output. 3. It can reduce peripheral vascular resistance (reduced afterload), but systolic blood pressure and pulse pressure generally remain unchanged, or only increase due to increased cardiac output. 4. It can reduce ventricular filling pressure and promote atrioventricular node conduction. 5. Myocardial contractility is enhanced, and coronary blood flow and myocardial oxygen consumption often increase. 6. Due to increased cardiac output, renal blood flow and urine volume often increase.

This product is a third-generation cephalosporin with a broad-spectrum antibacterial effect. It is a third-generation cephalosporin antibiotic produced against a variety of Gram-positive and Gram-negative bacteria. It has strong activity against Enterobacteriaceae. The MIC90 for Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Citrobacter fluorescens, indole-positive Proteus, Providencia and Serratia is between 0.12 and 0.25 mg/L. Enterobacter cloacae, Acinetobacter and Pseudomonas aeruginosa are poorly sensitive to this product. It has a strong antibacterial effect on Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis, and also has a good effect on hemolytic streptococci and pneumococci. The MIC for Staphylococcus aureus is 2 to 4 mg/L. Methicillin-resistant Staphylococci and enterococci are resistant to this product. Most Bacteroides fragilis are resistant to this product.

No specific pharmacological effects mentioned

It is a sulfonamide antibiotic that inhibits bacterial growth and reproduction. It has a strong inhibitory effect on meningococci, pneumonia, streptococci, and hemolytic streptococci, but has poor efficacy on staphylococcal infections. Bacteria may develop resistance to this product. The solubility of its metabolite acetylated in the body is low, and it is easy to precipitate crystals in the urinary tract. When used in combination with sodium bicarbonate, it makes the urine alkaline, reducing the precipitation of crystals. After oral administration, it is easily absorbed from the gastrointestinal tract, and can absorb more than 70% of the dose. After absorption, it can be widely distributed in tissues and body fluids throughout the body, and penetrate the blood-cerebrospinal fluid barrier to the cerebrospinal fluid to achieve a therapeutic effect. It can also cross the blood-placental barrier and enter the fetal blood circulation.

It is a sulfonamide antibiotic used for intestinal infections. Its antibacterial mechanism is that it is similar to para-aminobenzoic acid (PABA) in structure, and can compete with PABA on dihydrofolate synthase in bacteria, thereby preventing PABA from being integrated into folic acid required by bacteria as a raw material, reducing the amount of metabolically active tetrahydrofolate, which is an essential substance for bacteria to synthesize purine, thymidine and deoxyribonucleic acid (DNA), thus inhibiting the growth and reproduction of bacteria. After oral administration, most of it is excreted in feces in its original form.

When used in combination with sulfadiazine, the urine becomes alkaline, reducing the precipitation of sulfadiazine acetylated crystals.