Antipruritic and cooling effects

Antipruritic and cooling effects

Antipruritic and cooling effects

Antibacterial and antipruritic effects

Astringent and drying effect

Local antipruritic

Bactericidal or antibacterial and antipruritic

convergence

Local antipruritic

Local antipruritic

Bactericidal or antibacterial and antipruritic

Bactericidal or antibacterial and antipruritic

This product belongs to the azole antifungal drug, and it can inhibit the process of Candida albicans transforming from spores to invasive hyphae. This product has a broad-spectrum antifungal activity, and has good antibacterial effects on Epidermophyton, Trichophyton, Aspergillus, Chromatid fungi, Cryptococcus and Candida. It also has certain antibacterial activity against Sporothrix schenckii, Blastomyces dermatitidis, Coccidioides immitis, Histoplasma, etc. This product inhibits the biosynthesis of ergosterol, the main steroid of fungal cell membrane, by interfering with the activity of cytochrome P-450, damaging the fungal cell membrane and changing its permeability, resulting in leakage of important intracellular substances. This product can inhibit the biosynthesis of triglycerides and phospholipids of fungi, inhibit the activity of oxidases and peroxidases, and cause the accumulation of hydrogen peroxide in cells, leading to cell submicrostructure degeneration and cell necrosis.

By acting on the smooth muscle of the coronary and peripheral blood vessels and the atrioventricular node, inhibiting the influx of Ca2 into the cells, it exhibits vasodilation and prolongs the conduction time of the atrioventricular node, thus being effective for hypertension, arrhythmia, and angina pectoris. 1. Effect on blood pressure: 1) It can reduce hypertension under anesthesia and without anesthesia, but the effect is stronger under anesthesia than without anesthesia, and it has a stronger antihypertensive effect on blood pressure higher than normal blood pressure (rat). 2) While reducing blood pressure, it reduces peripheral vascular resistance and myocardial oxygen consumption, and increases cardiac output (dog). 3) It lowers blood pressure without reducing blood flow to the brain, coronary arteries, and kidneys. It also exhibits a sodium diuretic effect (dog, monkey). 2. Effect on arrhythmia: 1) It prolongs the conduction time, effective refractory period, and functional refractory period of the atrioventricular node, and exhibits an effect on supraventricular tachyarrhythmia (dog). 2) It inhibits supraventricular tachyarrhythmia caused by atrial electrical stimulation (rabbit). 3. Effects on myocardial ischemia: 1) Improve the balance of myocardial oxygen supply and demand ① Dilate the main coronary artery and side branches, increase blood flow to the ischemic part of the myocardium (dogs). ② Inhibit coronary artery spasm (pigs, humans). 2) Myocardial protection When myocardial ischemia occurs, it inhibits excessive influx of Ca2 into cells, maintains cardiac function and myocardial energy metabolism, and reduces the infarct focus (dogs, cats).