This product is an endogenous coenzyme B12, which participates in the one-carbon unit cycle and plays an important role in the transmethylation reaction of methionine synthesis from homocysteine. Animal experiments have found that this product is easier to enter neuronal organelles than cyanocobalamin, participates in the synthesis of thymidine nucleoside in brain cells and spinal cord neurons, promotes the utilization of folic acid and nucleic acid metabolism, and has a stronger effect on promoting nucleic acid and protein synthesis than cyanocobalamin. This product can promote axonal transport function and axonal regeneration, normalize the transport of axonal skeleton proteins in the sciatic nerve of diabetic rats induced by streptozotocin, and has an inhibitory effect on drug-induced neurodegeneration, such as neurodegeneration caused by adriamycin, acrylamide, and vincristine, and neurological diseases in spontaneously hypertensive rats. In rat tissue culture, it was found that this product can promote lecithin synthesis and neuronal myelination. This product can restore delayed synaptic transmission and neurotransmitter reduction to normal, restore end plate potential induction by increasing nerve fiber excitability, and restore acetylcholine in the brain of rats fed with choline-deficient feed to normal levels.

It is a vasodilator that can dilate coronary arteries and cerebral blood vessels, reduce myocardial oxygen consumption, improve microcirculation and resist platelet aggregation. Animal experiments have shown that: 1. The various total flavonoid compounds in Pueraria root can relax smooth muscles, while the contractile components may be substances such as choline, acetylcholine and carbazine R; 2. Pueraria root has a certain antihypertensive effect on normal and hypertensive animals; 3. Pueraria root total flavonoids and puerarin have a significant dilating effect on coronary arteries, which can dilate normal and spasmodic coronary arteries. After intravenous injection of 30mg/Kg, coronary blood flow can increase by 40% and vascular resistance can decrease by 29%; 4. Puerarin can also inhibit the release of 5-HT in platelets induced by thrombin.

Methylcobalamin is an endogenous coenzyme B12. It plays an important role as a coenzyme of methionine synthase in the transmethylation reaction of homocysteine to methionine. It is easily transferred to the organelles of nerve cells, thereby promoting the synthesis of nucleic acids and proteins. It promotes axonal transport and axonal regeneration, and has a certain improvement effect on sciatica neuropathy caused by streptozotocin in diabetic rats.

Dispel wind and dampness, dredge meridians and relieve pain

Dispel wind and dampness, dredge meridians and relieve pain

Dispel wind and dampness, dredge meridians and relieve pain

Dispel wind and dampness, dredge meridians and relieve pain

Dispel wind and dampness, dredge meridians and relieve pain

Dispel wind and dampness, dredge meridians and relieve pain

This product is a monoquaternary ammonium steroid medium-acting non-depolarizing muscle relaxant, similar in structure to pancuronium bromide, which blocks the conduction between nerve endings and striated muscles by competing with acetylcholine for nicotinic receptors located at the motor end plate of striated muscles. Unlike depolarizing neuromuscular blocking drugs such as succinylcholine, this product does not cause muscle fiber bundles to tremble. Intravenous injection of 0.08-0.1mg/kg is effective within 1 minute, reaching a peak in 3-5 minutes, and maintaining for 30-90 minutes. The muscle relaxant effect is 3 times stronger than that of tubocurarine chloride; it has no vagus nerve blocking effect. Since vecuronium bromide does not cause an increase in heart rate, it is suitable for patients with myocardial ischemia and heart disease, but the use of vagus nerve excitants and β-receptor blockers is prone to bradycardia. This product has a weak histamine release effect, and there are also bronchospasm and allergic reactions, but they are rare.