Relaxes vascular smooth muscle, activates guanylate cyclase by releasing nitric oxide (NO), increases cyclic guanosine monophosphate (cGMP) in smooth muscle cells, thereby dilating peripheral arteries and veins, reducing cardiac preload and afterload, increasing coronary artery perfusion, and reducing myocardial oxygen consumption.

This product is a calcium influx blocker (also known as a calcium channel blocker or calcium ion antagonist), which blocks extracellular calcium ions from entering myocardial and vascular smooth muscle cells through the calcium ion channels (slow channels) of the cell membrane. This product directly relaxes vascular smooth muscle, dilates peripheral arterioles, reduces peripheral resistance (afterload), and dilates coronary arteries, which can relieve coronary artery spasm, and has the effects of anti-hypertension and relieving angina pectoris.

1. Calcium influx blocker, blocking extracellular calcium ions from entering myocardial and vascular smooth muscle cells; 2. Directly relaxes vascular smooth muscle and has anti-hypertensive effect; 3. Relieves myocardial ischemia: dilates peripheral arterioles, reduces peripheral resistance and reduces myocardial energy consumption and oxygen demand; 4. Dilates coronary arteries and coronary arterioles, increasing myocardial oxygen supply; 5. It takes a long time to metabolize in the liver, so use with caution when liver function is impaired.

This product is a long-acting tricyclic antihistamine that can relieve seasonal allergic rhinitis or non-nasal symptoms by selectively antagonizing peripheral H1 receptors.