Acetylspiramycin Capsules

Acetylspiramycin is an acetylated derivative of spiramycin and belongs to the 16-membered macrolide class. This product has good antibacterial effects on Gram-positive cocci such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, and Enterococcus faecalis. It also has inhibitory effects on Listeria, Moraxella catarrhalis, Neisseria gonorrhoeae, Campylobacter fetus, Haemophilus influenzae, Legionella pneumophila, Bordetella pertussis, Bacteroides, Clostridium perfringens, Propionibacterium acnes, Peptococcus and Streptococcus, as well as Chlamydia, Mycoplasma, Toxoplasma, Cryptosporidium, etc. Intestinal Gram-negative bacilli are usually resistant. The mechanism of action is that acetylspiramycin binds to the 50S subunit of the ribosome of sensitive microorganisms, inhibiting RNA-dependent protein synthesis and exerting an antibacterial effect.

Main ingredients: This product is a mixture of four main components: monoacetylspiramycin II, monoacetylspiramycin III, diacetylspiramycin II and diacetylspiramycin III.

This product is off-white to slightly yellow powder or granules.

It is suitable for mild and moderate infections caused by sensitive Staphylococci, Streptococci and Streptococcus pneumoniae, such as pharyngitis, tonsillitis, sinusitis, otitis media, periodontitis, acute bronchitis, acute exacerbation of chronic bronchitis, pneumonia, non-gonococcal urethritis, skin and soft tissue infections. It can also be used for cryptosporidiosis or as an optional drug for the treatment of toxoplasmosis in pregnant women.

Adult dose: 0.2-0.3g once, 4 times a day, double the dosage for the first dose. Pediatric dose: 20-30mg/kg per day, divided into 4 doses.

Adverse reactions mainly include gastrointestinal reactions such as abdominal pain, nausea, and vomiting, which often occur when taking large doses of the drug. Most of them are mild and disappear on their own after stopping the drug. Allergic reactions are rare, mainly drug eruptions.

1. It is contraindicated for patients who are allergic to cephalosporins or penicillin. 2. It is contraindicated for patients who are allergic to trimethoprim. 3. It is contraindicated for newborns and premature infants. 4. It is contraindicated for patients with severe liver and kidney diseases. 5. It is contraindicated for patients with blood diseases.

Precautions for children: It is contraindicated for newborns and premature infants. Precautions for pregnancy and lactation: This product can penetrate the placenta, so the use of it in pregnant women needs to be determined after fully weighing the pros and cons. There is no data showing whether acetylspiramycin is excreted through breast milk, but since many macrolide drugs can be excreted through breast milk, lactating women should use this product with caution. If it must be used, breastfeeding should be suspended. Precautions for the elderly: Elderly patients with normal liver and kidney function do not need to reduce the dosage.

1 This product does not affect the metabolism of drugs such as aminophylline. 2 In patients receiving ergot derivatives, ergot poisoning has occurred when certain macrolides are used at the same time. There are currently no reports of interactions between ergot and acetylspiramycin, but this possibility still exists in theory. Therefore, acetylspiramycin and ergot should not be taken at the same time.

Sealed, store in a cool, dark and dry place.

0.1g (100,000 units)

36 months

Jinri Pharmaceutical (China) Co., Ltd.

• Founded in:

  1991-07-05

• Address:

  Jinri Industrial Village, Jinri Road, Tongan District, Xiamen

• Tax NO.:

  91350200612009145K

• Registered Funds:

  225.5 million yuan

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