Erythromycin Granules

This product belongs to the macrolide antibiotics, which is the dodecyl sulfate of erythromycin propionate. It has antibacterial activity against Staphylococcus, various groups of streptococci and Gram-positive bacilli. Neisseria, Haemophilus influenzae, Bordetella pertussis, etc. may also be sensitive to this product. This product also has antibacterial activity against various anaerobic bacteria except Bacteroides fragilis and Fusobacterium; it also has inhibitory effects on Legionella, Campylobacter fetus, some spirochetes, Mycoplasma pneumoniae, Rickettsia and Chlamydia. This product is an antibacterial agent, but it also has a bactericidal effect on certain bacteria at high concentrations. This product can pass through the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor site (P site), blocking the transfer RNA (t-RNA) binding to the P site, and also blocking the displacement of the polypeptide chain from the acceptor site (A site) to the P site, thereby inhibiting bacterial protein synthesis. This product is only effective against bacteria that actively divide

Main ingredients: Erythromycin.

It is used as an alternative medicine for the treatment of the following infections in patients allergic to penicillin: 1. Acute tonsillitis, acute pharyngitis, sinusitis caused by hemolytic streptococci, pneumococcus, etc.; scarlet fever and cellulitis caused by hemolytic streptococci; diphtheria and diphtheria carriers; gas gangrene, anthrax, tetanus; actinomycosis; syphilis; listeriosis, etc.; 2. Legionnaires' disease; 3. Mycoplasma pneumonia; 4. Chlamydia pneumoniae pneumonia; 5. Urinary and reproductive system infections caused by other Chlamydia and Mycoplasma; 6. Chlamydia trachomatis conjunctivitis; 7. Oral infections caused by anaerobic bacteria;

Oral administration: adults 1-2 g per day divided into 3-4 times; children 20-30 mg/kg per day divided into 3-4 times according to body weight. See the instructions for details.

1. Gastrointestinal reactions include diarrhea, nausea, vomiting, upper abdominal pain, pain in the mouth and tongue, decreased appetite, etc., and the incidence is related to the dose. 2. Hepatotoxicity is rare. Patients may experience fatigue, nausea, vomiting, abdominal pain, fever, abnormal liver function, and occasionally jaundice. 3. When used in large doses (ge; 4g/day), especially in patients with liver and kidney diseases or elderly patients, hearing loss may occur, which is mainly related to excessive blood drug concentration (12mg/L). Most of them can be recovered after drug withdrawal. 4. Allergic reactions are manifested as drug fever, rash, eosinophilia, etc., with an incidence of about 0.5% to 1%. 5. Others, occasionally arrhythmias, oral or vaginal candidiasis.

1. It is contraindicated for those who are allergic to erythromycin drugs; 2. Pregnant women should use it with caution, and breastfeeding women should stop breastfeeding when using it.

Precautions during pregnancy and lactation: Pregnant women should use with caution, and lactating women should suspend breastfeeding when using this product.

1. This product can inhibit the metabolism of anti-epileptic drugs such as carbamazepine and valproic acid, resulting in increased blood concentrations and toxic reactions. Combination with fentanyl can inhibit the metabolism of the latter and prolong its duration of action. Combination with antihistamines such as astemizole or terfenadine can increase cardiac toxicity, and combination with cyclosporine can increase the latter's blood concentration and produce nephrotoxicity. 2. This product has an antagonistic effect with chloramphenicol and lincosamides, and it is not recommended to use them at the same time. 3. This product is an antibacterial agent and can interfere with the bactericidal efficacy of penicillin. Therefore, when rapid bactericidal effects are required, such as the treatment of meningitis, the two should not be used at the same time. 4. Patients who take warfarin for a long time can prolong the prothrombin time when using this product, thereby increasing the risk of bleeding. Elderly patients should pay special attention. When the two must be used at the same time, the dose of warfarin should be appropriately adjusted and the prothrombin time should be closely observed. 5Except for dihydroxypropylphylline, the simultaneous use of this product with xanthine drugs can reduce the hepatic clearance of aminophylline, leading to increased serum aminophylline concentrations and (or) increased toxic reactions. This phenomenon is more likely to occur after 6 days of combined use, and the reduction in aminophylline clearance is proportional to the serum peak value of this product. Therefore, the dose of xanthine drugs should be adjusted during and after the combination of the two. 6This product may enhance hepatotoxicity when used in combination with other hepatotoxic drugs. 7The combination of large doses of this product with ototoxic drugs, especially in patients with renal impairment, may increase ototoxicity. 8When used in combination with lovastatin, its metabolism can be inhibited and blood concentrations can be increased, which may cause rhabdomyolysis; when used in combination with midazolam or triazolam, the clearance of both can be reduced and their effects can be enhanced.

Keep away from light and store in sealed container.

Calculated as erythromycin: 250 mg (250,000 units)

Shaanxi Bangsheng Pharmaceutical Co., Ltd.

• Founded in:

  2004-05-10

• Address:

  North Section of Mingguang Road, Caotan Ecological Industrial Park, Economic Development Zone, Xi'an, Shaanxi Province

• Tax NO.:

  916100007588434071

• Registered Funds:

  10 million yuan

• Email:

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