Phenylbutazone tablets

[Pharmacology and Toxicology] This product is a non-steroidal anti-inflammatory drug with strong anti-inflammatory effect, good effect on inflammatory pain, promoting uric acid excretion, and weak antipyretic effect. [Pharmacology and Toxicology] It is easily absorbed in the gastrointestinal tract, and the peak blood concentration is about 2 hours. Vd is 120ml/kg, and the blood concentration does not increase with increasing doses. 98% is bound to plasma proteins. It is mainly metabolized slowly by oxidation in the liver, and one of its metabolites, hydroxyphenylbutazone, still has anti-inflammatory activity. This product is slowly metabolized and excreted, with an average elimination half-life of about 70 hours.

The main ingredient of this product is: Phenylbutazone.

This product is a sugar-coated tablet or a film-coated tablet, which appears white after removing the coating.

It is mainly used to treat rheumatoid arthritis, rheumatoid arthritis, and ankylosing spondylitis. Large doses of this drug can reduce the reabsorption of urate by the renal tubules and promote urate excretion, so it can be used to treat acute gout.

1. For the treatment of arthritis, take orally 0.1-0.2g (1-2 tablets) 3 times a day after meals. The total daily amount should not exceed 0.8g (8 tablets). If there is no adverse reaction after one week and the condition improves, you can continue to take it, and the dosage should be reduced to the maintenance dose: 0.1-0.2g (1-2 tablets) each time, once a day. 2. For acute gout, take orally: initial dose 0.2-0.4g (2-4 tablets), then 0.1-0.2g (1-2 tablets) every 6 hours. After the symptoms improve, reduce to 0.1g (1 tablet) each time, 3 times a day, for 3 consecutive days.

1. Common adverse reactions include nausea, vomiting, gastrointestinal discomfort, water and sodium retention, edema, rash, etc.; 2. It may also cause diarrhea, dizziness, headache, and long-term high-dose gastrointestinal ulcers and gastrointestinal bleeding; 3. Occasionally cause hepatitis, jaundice, nephritis, hematuria, exfoliative dermatitis, erythema multiforme, goiter, granulocytopenia and thrombocytopenia; 4. Blood counts should be checked after taking the drug for more than one week. If fever, sore throat, rash, jaundice and tarry stools occur, the drug should be discontinued immediately.

It is contraindicated for those who are allergic to aspirin, have a history of ulcers, edema, hypertension, mental illness, epilepsy, bronchial asthma, heart disease, and impaired liver and kidney function.

Precautions for children: Children are allergic to this product, so avoid using it. Precautions for pregnancy and lactation: Pregnant women are prohibited. Precautions for the elderly: Elderly patients should use it with caution.

1. This product can inhibit the metabolism of coumarin anticoagulants and sulfonylurea hypoglycemic drugs, and can displace them from the plasma protein binding site, thereby significantly enhancing their effects and toxicity, and can cause hypoglycemia or bleeding symptoms. Combination with drugs that increase the activity of liver microsomal enzymes can reduce the elimination half-life of this drug. 2. It should be avoided to be used in combination with other drugs with bone marrow suppression. 3. This product combined with the diuretic triamterene can cause renal damage.

Keep away from light and store in sealed container.

0.1g

24 months

Jinghua Pharmaceutical Group Co., Ltd.

• Founded in:

  1994-01-03

• Address:

  No. 9 Xingtai Road, Gangzha Economic Development Zone, Nantong City

• Tax NO.:

  91320600138297660P

• Registered Funds:

  814.180908 million yuan

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