Clotrimazole tablets

This product belongs to the azole antifungal drug, and it can inhibit the process of Candida albicans transforming from spores to invasive hyphae. This product has a broad-spectrum antifungal activity, and has good antibacterial effects on Epidermophyton, Trichophyton, Aspergillus, Chromatid fungi, Cryptococcus and Candida. It also has certain antibacterial activity against Sporothrix schenckii, Blastomyces dermatitidis, Coccidioides and Histoplasma. This product has poor effects on Aspergillus, some dark spores, Mucor and other genus. This product inhibits the biosynthesis of ergosterol, the main steroid of fungal cell membrane, by interfering with the activity of cytochrome P-450, damaging the fungal cell membrane and changing its permeability, resulting in leakage of important intracellular substances. This product can inhibit the biosynthesis of triglycerides and phospholipids of fungi, inhibit the activity of oxidases and peroxidases, and cause the accumulation of hydrogen peroxide in cells, leading to cell submicrostructure degeneration and cell necrosis.

The main ingredient of this product is clotrimazole.

This product is white tablets.

It is used to prevent and treat oral and esophageal Candida infections in immunosuppressed patients. However, due to its poor oral absorption, poor efficacy in treating deep fungal infections, and common adverse reactions, it is now rarely used and is only used topically.

Oral administration: 0.25-1g at a time, 0.75-3g per day. Children: 20-60mg/kg per day, divided into 3 doses.

1. Common gastrointestinal reactions after oral administration, generally after starting to take the drug, there will be anorexia, nausea, vomiting, abdominal pain, diarrhea, etc., and severe cases often need to stop taking the drug. 2. Hepatotoxicity: Since most of this product is metabolized in the liver, liver damage may occur, causing elevated serum bilirubin, alkaline phosphatase and aminotransferase, which can be restored after stopping the drug. 3. Occasionally, temporary neuropsychiatric abnormalities may occur, manifested as depression, hallucinations and disorientation. Once such reactions occur, treatment must be discontinued.

It is contraindicated for patients with liver dysfunction, granulocytopenia, adrenal cortex insufficiency and allergy to this product.

Precautions for children: The safety and effectiveness of the drug for children under 3 years old have not been established. Precautions for pregnancy and lactation: Animal experiments show that it is embryotoxic when used at 100 times the human dose. Pregnant women should weigh the pros and cons before deciding whether to use it. There is no data on whether this product is secreted in breast milk. However, since many drugs are secreted in breast milk, breastfeeding women should use it with caution. Precautions for the elderly: It is not clear yet.

This product has no synergistic effect with nystatin, amphotericin B and flucytosine against Candida albicans.

Keep away from light and store in sealed container.

0.25g

24 months

Shanxi Zhendong Anxin Biopharmaceutical Co., Ltd.

• Founded in:

  1992-06-12

• Address:

  No. 908, Jicheng Road, Huitong Industrial Park, Jinzhong Development Zone, Shanxi Demonstration Zone, Jinzhong City, Shanxi Province

• Tax NO.:

  91140700602052641X

• Registered Funds:

  170 million yuan

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