Berberine Trimethoprim Capsules

Berberine hydrochloride and trimethoprim have synergistic antibacterial effects. Berberine hydrochloride has inhibitory effects on a variety of Gram-positive and Gram-negative bacteria in vitro, among which hemolytic streptococci, Staphylococcus aureus, Vibrio cholerae, Neisseria meningitidis, Shigella, Salmonella typhi, Corynebacterium diphtheriae, etc. have stronger inhibitory effects. It also has a certain inhibitory effect on amoeba. Trimethoprim mainly interferes with bacterial folate metabolism, selectively inhibits dihydrofolate reductase, and prevents nucleic acid synthesis. Therefore, the antibacterial effect of the two combined is stronger than that of a single drug, and the drug-resistant strains are reduced.

This product is a compound preparation, and its components are: each tablet contains 100 mg of berberine hydrochloride and 50 mg of trimethoprim.

This product is a capsule, the contents are yellow granules, odorless and bitter.

Used for intestinal infections such as gastroenteritis and bacillary dysentery caused by sensitive bacteria.

Take 1-3 capsules at a time, 3 times a day.

Nausea, vomiting, drug rash, and diarrhea will disappear after stopping the drug; itching and rash may occur, and occasionally severe exudative erythema multiforme may occur; aseptic meningitis may occasionally occur, with headaches, stiff neck, etc.

1. It is contraindicated for those who are allergic to berberine hydrochloride, trimethoprim and sulfonamides; 2. It is contraindicated for children with glucose-6-phosphate dehydrogenase deficiency; 3. It is contraindicated for newborns and infants under 2 months old; 4. During pregnancy, the use of this product must be decided after weighing the pros and cons; 5. Elderly patients should pay attention to blood tests when taking this product due to their reduced resistance and weakened metabolic capacity. If serious adverse reactions occur, the medication should be stopped immediately.

Precautions for children: It is forbidden to use in newborns and infants under 2 months old. Precautions for pregnancy and lactation: During pregnancy, the use of this product must be decided after weighing the pros and cons. Pregnant women and lactating women should use it with caution. Precautions for the elderly: Elderly patients have reduced resistance and weakened metabolic capacity. When taking this product, they should pay attention to blood tests. If serious adverse reactions occur, the drug should be stopped immediately.

1. The interaction between berberine hydrochloride and other drugs is still unclear; 2. Trimethoprim; (1) When used simultaneously with bone marrow suppressants, the chances of leukopenia and thrombocytopenia increase; (2) When used simultaneously with dapsone, the blood concentrations of both drugs increase. The increase in dapsone blood concentration increases and aggravates adverse reactions, especially the occurrence of methemoglobinemia; (3) When anti-tumor drugs and 2,4-diaminopyrimidine drugs are used simultaneously, it is also not advisable to use this product between courses of treatment with other folic acid antagonists because of the possibility of bone marrow aplasia or megaloblastic anemia; (4) When used simultaneously with reserpine, trimethoprim elimination increases and plasma half-life shortens; (5) When used simultaneously with cyclosporine, renal toxicity increases; (6) It interferes with the hepatic metabolism of phenytoin, increases the half-life of phenytoin,

Keep away from light and store in airtight container.

24 months

Guangxi Wuzhou Sanjian Pharmaceutical Co., Ltd.

• Founded in:

  2002-12-11

• Address:

  No. 32, Fudian Shangchong, Xijiang 4th Road, Wuzhou City

• Tax NO.:

  91450400745110909P

• Registered Funds:

  25 million yuan

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