Hydroxycamptothecin for injection

Hydroxycamptothecin (HCPT) is a cell cycle-specific drug that mainly acts in the S phase. Recently, it has been found to have a targeted and selective inhibitory effect on DNA topoisomerase I, which catalyzes the unwinding of supercoiled DNA for replication and transcription. This product inhibits TOPOI and inhibits the replication and transcription of cancer cells. This product has no obvious cross-resistance with other commonly used anticancer drugs.

The chemical name is: (S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione.

This product is a yellow freeze-dried loose block or powder of hydroxycamptothecin, odorless, easily soluble in water. The pH value of the aqueous solution is 8.0-9.5.

Anti-tumor drug, suitable for primary liver cancer, gastric cancer, bladder cancer, rectal cancer, non-small cell lung cancer, head and neck epithelial cancer, leukemia and other malignant tumors.

1. Primary liver cancer: intravenous injection, 4-6 mg per day, dissolved in 20 ml of 0.9% sodium chloride injection, slowly injected, or as directed by a doctor. Hepatic artery administration, 4 mg plus 10 ml of 0.9% sodium chloride injection, perfused once a day, 15-30 days as a course of treatment; 2. Gastric cancer: intravenous injection, 4-6 mg per day, dissolved in 20 ml of 0.9% sodium chloride injection, slowly injected, or as directed by a doctor. Head and neck epithelial cancer: intravenous injection, 4-6 mg per day, dissolved in 20 ml of 0.9% sodium chloride injection, slowly injected, or follow the doctor's advice; 3 Bladder cancer: add high-frequency diathermy for 100 minutes after bladder instillation, and gradually increase the dose from 10 mg to 20 mg twice a week, 10-15 times as a course of treatment; 4 Rectal cancer: catheterization of the inferior epigastric artery, enter about 25 cm, equivalent to the upper part of the branch of the tube under the mesentery, add 6-8 mg of hydroxycamptothecin to 500 ml of 0.9% sodium chloride injection and drip it through the artery, once a day, 15-20 times as a course of treatment; 5 Non-small cell lung cancer: 12 mg/m2 per day, dissolved in 100 ml of 0.9% sodium chloride injection, drip it intravenously at a constant speed within 30 minutes, and continue to use it for 5 days; 6 Leukemia: The adult dose is 6-8 mg/m2/day, added to 0.9% sodium chloride injection and dripped intravenously, and continued to be administered for 30 days as a course of treatment.

1. Effect on the digestive system: Mainly manifested in nausea, loss of appetite and other reactions, but not serious, generally can adhere to the treatment, after stopping the drug, the above symptoms quickly alleviated and disappeared; 2. Effect on the hematopoietic system: bone marrow suppression is mild, white blood cells have a partial decrease, but can be maintained at 1 times; 109 / L or above; no obvious inhibitory effect on red blood cells and platelets was found; 3. Effect on the urinary system: a small number of cases have urinary urgency, urinary pain and hematuria, which gradually disappear one week after stopping the drug; 4. Other reactions: a small number of cases have hair loss, which can resume growth on its own after stopping the drug.

Keep in a sealed, dark and cool place.

5mg (calculated as C20H16N2O5)

ShenZhen Main Luck Pharmaceuticals Inc

• Founded in:

  1990-07-04

• Address:

  Wanle Pharmaceutical Building, National Biomedicine Industry Base, Lanzhu East Road, Pingshan New District, Shenzhen

• Tax NO.:

  91440300618861849X

• Registered Funds:

  $19,544,550

• Website:

  Log in to view

• Email:

  Log in to view