Calcium folinate for injection

The main ingredient and its chemical name are: Calcium folinate. The chemical name is: 5-methyl-5,6,7,8-tetrahydropteroyl-L-monoglutamic acid calcium salt. Its structural formula is: Molecular formula: C20H21CaN7O7bull;5H2O Molecular weight: 601.61.

This product is yellow loose mass or powder.

It is mainly used as an antidote for folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim). This product is often used clinically to prevent severe toxic effects caused by overdose or high-dose treatment of methotrexate. When oral folic acid is ineffective, it is also used for megaloblastic anemia caused by stomatitis, diarrhea, malnutrition, pregnancy or infancy, but it is not suitable for vitamin B12 deficiency anemia. In recent years, calcium folinate has been used as an adjuvant treatment for colon and rectal cancer, and combined with fluorouracil, it can prolong survival.

The prescribed dosage and administration time should be strictly followed and should not be changed at will. Additional dosage or discontinuation of medication must be agreed upon by the responsible physician. For intramuscular injection as a "rescue" therapy for methotrexate, the dosage of this product is best determined based on blood drug concentration. The general dosage is 9-15 mg/m2 based on body surface area, once every 6-8 hours for 2 days until the serum concentration of methotrexate is below 5×10-8 mol/L. As an antidote for pyrimethamine or trimethoprim, each dose is 9-15 mg intramuscularly, depending on the poisoning situation. For anemia, 1 mg is injected intramuscularly daily. Intravenous injection as an adjuvant treatment for colorectal cancer, combined with fluorouracil

Rarely, skin rash may occur. Look for allergic reactions such as hives or asthma.

It is contraindicated in pernicious anemia and megaloblastic anemia caused by vitamin B12 deficiency.

The use of this product in large doses together with barbiturates, primidone or phenytoin sodium may affect the anti-epileptic effect.

Store in a sealed container away from light.

Calculated as C20H23N7O7 3mg

Beijing SL Pharmaceutical Co., Ltd.

• Founded in:

  1994-12-24

• Address:

  4th Floor, Building 1, Bitongyuan, No. 69, Fushi Road, Haidian District, Beijing

• Tax NO.:

  91110000102299779W

• Registered Funds:

  1,027.35 million yuan

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