Granisetron Hydrochloride and Sodium Chloride Injection

Pharmacological action: This product is a highly selective 5HT3 receptor antagonist, which has a good preventive and therapeutic effect on nausea and vomiting caused by radiotherapy, chemotherapy and surgery. Factors such as radiotherapy, chemotherapy and surgical operations can cause enterochromaffin cells to release 5HT, and 5HT can activate the 5HT3 receptors of the central nervous system or vagus nerve to cause vomiting reflex. The mechanism of this product in controlling nausea and vomiting is to antagonize the 5HT3 receptors in the central chemoreceptor area and peripheral vagus nerve endings, thereby inhibiting the occurrence of nausea and vomiting. This product has high selectivity and no side effects such as extrapyramidal reactions and excessive sedation. Toxicological studies: Reproductive toxicity: When the subcutaneous dose of this product reaches 6 mg/Kg/day (based on body surface area, it is 97 times the recommended dose for clinical intravenous administration),

The main ingredient of this product is granisetron hydrochloride, and its chemical name is 1-methyl-N-(endo-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide hydrochloride.

This product is a colorless or almost colorless clear liquid.

Used for nausea and vomiting caused by radiotherapy and cytotoxic chemotherapy.

Intravenous drip, the adult dose is usually 3 mg, administered 30 minutes before treatment. Most patients only need to take the drug once, and the prevention effect on nausea and vomiting can last for more than 24 hours. If necessary, the number of doses can be increased by 1 to 2 times, but the maximum daily dose should not exceed 9 mg.

Common side effects include headache, fatigue, fever, constipation, and occasional transient asymptomatic increase in liver transaminase. These reactions are mild and can be recovered without special treatment.

1. Patients with gastrointestinal obstruction are prohibited from using this product. 2. Patients who are allergic to this product are prohibited from using this product.

Keep in a dark place and sealed. The validity period is tentatively set at one and a half years.

50ml: Granisetron 3mg and sodium chloride 0.45g

Huaren Pharmaceuticals (Rizhao) Co., Ltd.

• Founded in:

  2001-10-31

• Address:

  No. 39 Fuyang Road, Rizhao City

• Tax NO.:

  91371102732618201L

• Registered Funds:

  36 million yuan

• Website:

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