Prazosin Hydrochloride Tablets

1 Prazosin hydrochloride is a selective postsynaptic α1 receptor blocker and a quinazoline derivative. This product can relax vascular smooth muscle, dilate peripheral blood vessels, reduce peripheral vascular resistance, and lower blood pressure. 2 This product dilates arteries and veins, reduces cardiac preload and afterload, decreases left ventricular end-diastolic pressure, improves cardiac function, and has a rapid onset of action in the treatment of heart failure, reaching a peak in 1 hour and lasting for 6 hours. 3 This product has little effect on renal blood flow and glomerular filtration rate, and can relieve dysuria in patients with prostatic hyperplasia by blocking α1 receptors in the bladder neck, prostate capsule and glands, and urethra. 4 Animal experiments have shown that most drugs bind to α1 acid glycoprotein, and only 5% of the drugs are in the free form.

The main ingredient and chemical name of this product are: 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine hydrochloride

This product is white tablets

hypertension

Oral administration, 0.5mg~1mg once, 2~3 times a day (the first dose is 0.5mg, taken before bedtime). Gradually adjust to 6mg~15mg a day according to the efficacy, taken in 2~3 times. The efficacy will not be further increased after the daily dose exceeds 20mg.

1 This product can cause syncope, which is mostly caused by postural hypotension. It occasionally occurs when the ventricular rate is 100-160 beats/min. It usually occurs 30-90 minutes after the first dose or when used in combination with other antihypertensive drugs. It is more likely to occur in patients with a low-sodium diet and those taking beta-blockers. If the first dose is changed to 0.5 mg and taken before bedtime, this adverse reaction can be prevented or alleviated; stopping the use of diuretics one day before taking this drug can also alleviate the "first phenomenon." This side effect is self-limiting and will not occur again in most cases. 2 Dizziness and drowsiness may occur after the first dose of the drug. Driving and dangerous work should be avoided on the first day after the first dose or increase in dosage. Dizziness may occur when the body position changes from lying to standing. Getting up slowly can avoid it.

1 When used with calcium antagonists, the antihypertensive effect is enhanced and the dosage must be adjusted appropriately. The same precautions should be taken when used with other antihypertensive drugs or diuretics. 2 When used with thiazide diuretics or beta-blockers, the antihypertensive effect is enhanced and water and sodium retention may be reduced. When used in combination, the dosage should be adjusted to obtain the minimum effective dose of each drug. 3 When used with non-steroidal anti-inflammatory analgesics, especially indomethacin, the antihypertensive effect of this product may be weakened. 4 When used with sympathomimetic drugs, the antihypertensive effect of this product is weakened. 5 No adverse side effects occur when this drug is used in combination with the following drugs: digoxin; insulin; sulfonylurea hypoglycemic drugs: including hypoglycemic spirit, tolbutamide, chlorosulfuron

Keep in a light-proof and sealed place

1mg

Changchun Norman Bethune Pharmaceutical Co., Ltd.

• Founded in:

  1985-12-06

• Address:

  No. 358, Chuangxin Road, High-tech Industrial Development Zone, Changchun City, Jilin Province

• Tax NO.:

  91220101123997525C

• Registered Funds:

  64.4778 million yuan

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