Compound Sodium Chloride Injection

Compound sodium chloride is a drug for replenishing body fluids and regulating water and electrolyte balance. It contains water for injection, Na and Cl- ions, and a small amount of K and Ca ions. Sodium and chloride are important electrolytes in the body, mainly present in extracellular fluid, and play a very important role in maintaining the normal blood and extracellular fluid volume and osmotic pressure of the human body. The normal serum sodium concentration is 135-145mmol/L, accounting for 92% of plasma cations and 90% of total osmotic pressure, so the amount of plasma sodium plays a decisive role in osmotic pressure. The normal serum chloride concentration is 98-106mmol/L. The human body mainly regulates through the hypothalamus, posterior pituitary and kidneys to maintain the stability of body fluid volume and osmotic pressure. In addition to the above effects, compound sodium chloride can also supplement a small amount of potassium ions and calcium ions.

This product is a compound preparation containing 0.85% sodium chloride, 0.03% potassium chloride and 0.033% calcium chloride.

This product is a colorless, clear liquid with a slightly salty taste.

1 Water loss due to various reasons, including hypotonic, isotonic and hypertonic water loss; 2 Hyperosmotic non-ketotic coma, the use of isotonic or hypotonic sodium chloride can correct water loss and hyperosmotic state; 3 Hypochloremic metabolic alkalosis. When the patient cannot eat or eats less for some reason and needs to supplement the daily physiological needs, sodium chloride injection or compound sodium chloride injection can generally be given. Because this product contains very little potassium, hypokalemia needs to be supplemented as needed.

When treating dehydration, the amount, type, route and speed of fluid replacement should be determined according to the degree and type of dehydration. 1 Hypertonic dehydration When hypertonic dehydration occurs, the osmotic concentration of brain cells and cerebrospinal fluid increases. If the treatment causes the sodium concentration and osmotic concentration of plasma and extracellular fluid to drop too quickly, it may cause edema. Therefore, it is generally believed that within 48 hours after the start of treatment, the plasma sodium concentration should not drop by more than 0.5mmol/L per hour. If the patient is in shock, sodium chloride injection should be given first, and colloid should be supplemented as appropriate. When the shock is corrected, the blood sodium is 155mmol/L, and the plasma osmotic concentration is 350mOsm/L, 0.6% hypotonic sodium chloride injection can be given. When the plasma osmotic concentration is <330mOsm/L, 0.9% sodium chloride injection should be used instead. The total amount of fluid replacement is calculated according to the following formula for reference: Generally, half of the amount is replenished on the first day, and the remaining amount is replenished within the next 2 to 3 days, and it is adjusted as appropriate according to cardiopulmonary and renal function. 2 Isotonic dehydration principle: Isotonic solution, such as 0.9% sodium chloride injection or compound sodium chloride injection, is given. However, the chloride concentration of the above solution is significantly higher than that of plasma. Large-scale use alone can cause hyperchloremia. Therefore, 0.9% sodium chloride injection and 1.25% sodium bicarbonate or 1.86% (1/6M) sodium lactate can be prepared in a ratio of 7:3 and then replenished. The latter has a chloride concentration of 107mmol/L and can correct metabolic acidosis. The amount of replenishment can be calculated by body weight or hematocrit for reference. ① Calculated by body weight: fluid replacement (L) = (weight loss (kg) × 142) / 154; ② Calculated by hematocrit: fluid replacement (L) = (actual hematocrit - normal hematocrit × body weight (kg) × 0.2) / normal hematocrit. Normal hematocrit is 48% for men and 42% for women. 3 Hypotonic dehydration In severe hypotonic dehydration, the solutes in brain cells decrease to maintain cell volume. If the treatment causes the plasma and extracellular fluid sodium concentration and osmotic concentration to rise rapidly, brain cell damage may occur. It is generally believed that when blood sodium is lower than 120mmol/L, the treatment causes the blood sodium to rise at a rate of 0.5mmol/L per hour, not exceeding 1.5mmol/L per hour. When blood sodium is lower than 120mmol/L or when central nervous system symptoms occur, 3% to 5% sodium chloride injection can be given by slow drip. It is generally required to increase blood sodium concentration to above 120mmol/L within 6 hours. Sodium supplementation (mmol/L) = [142-actual blood sodium concentration (mmol/L)] × body weight (kg) × 0.2. When blood sodium rises to above 120-125mmol/L, isotonic solution can be used instead or hypertonic glucose injection or 10% sodium chloride injection can be added to isotonic solution as appropriate. 4. For hypochloremic alkalosis, give 500-1000ml of 0.9% sodium chloride injection or compound sodium chloride injection (Ringer's solution), and the dosage will be determined based on the severity of the alkalosis.

1. Excessive and rapid infusion can cause water and sodium retention, resulting in edema, increased blood pressure, increased heart rate, chest tightness, dyspnea, and even acute left heart failure. 2. Inappropriate administration of hypertonic sodium chloride can cause hypernatremia. 3. Excessive and rapid administration of hypotonic sodium chloride can cause hemolysis, cerebral edema, etc.

1. Edema diseases, such as nephrotic syndrome, ascites due to liver cirrhosis, congestive heart failure, acute left heart failure, cerebral edema and idiopathic edema. 2. Oliguria in acute renal failure, and patients with chronic renal failure who have decreased urine volume and poor response to diuretics. 3. Hypertension and hypokalemia.

Precautions for children: The amount and speed of fluid replacement should be strictly controlled. Precautions for pregnancy and lactation: Not yet clear. Precautions for the elderly: The amount and speed of fluid replacement should be strictly controlled.

Not yet clear.

Keep away from light and store in a sealed container.

500ml

24 months

Shijiazhuang No.4 Pharmaceutical Co., Ltd.

• Founded in:

  1994-06-28

• Address:

  No. 518, Huaian East Road, Shijiazhuang High-tech Industrial Development Zone

• Tax NO.:

  911301001044060055

• Registered Funds:

  950 million yuan

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