Nalmefene hydrochloride

Nalmefene hydrochloride, the excipients are sodium chloride, hydrochloric acid and water for injection.

This product is a colorless clear liquid.

Nalmefene is used to completely or partially reverse the effects of opioids, including respiratory depression, caused by natural or synthetic opioids.

General principles: This product can reverse the undesirable opioid effects through dose titration. Because it is not expected to reverse the loss of pain and cause harm or withdrawal reactions, the medication should not be continued once a sufficient reversal effect is achieved. Recommended dose for reversing postoperative opioid inhibition: Use a dose concentration of 100μg/ml, see the initial dose in Table 1. The purpose of postoperative treatment with nalmefene is to reverse the excessive inhibitory effects of opioids, not to cause complete reversal and acute pain. The initial dose is 0.25μg/kg, and the dose can be increased by 0.25μg/kg after 2-5 minutes. Stop the drug immediately when the expected opioid reversal effect is achieved. Cumulative doses greater than 1.0μg/kg will not increase efficacy.

For healthy users, nalmefene is well tolerated and has no serious adverse reactions, even at doses of 15 times or more than the recommended dose. For a small number of patients, when the dose of this product exceeds the recommended dose, the symptoms produced by nalmefene show a reversal of the effects of endogenous opioids (such as other anesthetic antagonists previously reported). These symptoms (such as nausea, chills, myalgia, irritability, abdominal cramps and joint pain) are often transient and have a low incidence.

Sealed, store in a cool dark place (avoid light and not exceed 20℃).

Lingbao City Yuxi Pharmaceutical Co., Ltd.

• Founded in:

  1999-05-19

• Address:

  West section of Station Road, Lingbao City

• Tax NO.:

  914112827066645112

• Registered Funds:

  6.53 million yuan

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