Cefonicid Sodium for Injection

This product is a second-generation cephalosporin for intravenous or intramuscular injection. This product has a wider antibacterial spectrum against Gram-negative bacilli than the first-generation cephalosporins. It has good antibacterial activity similar to cefoxitin against Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Citrobacter, Providencia and Enterobacter, but its activity against indole-positive Proteus, Morganella, Providencia and some Klebsiella is lower than that of cefoxitin. It has satisfactory activity against gonococci of influenza bacilli, including beta-lactamase-producing strains. Like other second-generation cephalosporins, Pseudomonas, Serratia and Acinetobacter are resistant to this product. This product is effective against most Gram-positive cocci. Its activity against Staphylococcus aureus is similar to that of cefoxitin and cefuroxime, but lower than that of cefoxitin, cephalothin and cefazolin. 90% of the strains can be inhibited by the concentration of 4.0-8.3 mg/L of this product. Most streptococci, including Streptococcus pneumoniae, Streptococcus pyogenes and Group B Streptococcus, are sensitive to this product. Staphylococcus epidermidis is relatively resistant to this product. Fecal Streptococcus, Staphylococcus aureus and methicillin-resistant strains of Staphylococcus epidermidis are all resistant to this product. The activity of this product against anaerobic bacteria has not been well studied, and Bacteroides fragilis is resistant to this product. The minimum bactericidal concentration (MBC) of this product for Staphylococcus aureus, Group B Streptococcus and Escherichia coli is significantly higher than its minimum inhibitory concentration (MIC). This product is very stable to type I beta-lactamase, but can be slowly hydrolyzed by type IIIa, IIIb and V beta-lactamase, while only type IV beta-lactamase is sensitive.

Cefonicid Sodium

This product is white to off-white crystalline powder, odorless.

It is suitable for Gram-positive and some Gram-negative bacterial infections, but ineffective against Pseudomonas aeruginosa. It is mainly used clinically for various infections caused by sensitive bacteria, such as respiratory tract infections, pyelonephritis, urinary tract infections, peritonitis, bacteremia, and infections of the skin, soft tissue, bones, and joints. Due to its high urine concentration, it has a high efficacy in treating urinary tract infections.

Intramuscular injection, intravenous injection or intravenous drip: Adults generally take 0.5g-1.0g per day, divided into 1-2 times; for severe and refractory infections, the dosage for adults can be increased to 2g per day; for children, the dosage can be increased to 25mg-150mg/kg per day, depending on the severity of infection.

The most commonly reported adverse reactions were similar to those of other cephalosporins and penicillins and included mild to moderate injection site pain, allergic reactions, eosinophilia, thrombocytosis, and abnormal liver function tests. Leukopenia and neutropenia occurred in 0.4% and 0.3% of patients, respectively.

It is contraindicated in patients who are allergic to cephalosporins.

When used together with nefrotossici drugs (such as antibiotics, etc.), renal function must be monitored at all times. 1. It cannot be administered in the same container as oxysugar drugs. 2. When used in combination with prilocaine, it can slow down renal excretion, increase blood drug concentration levels, and cause toxicity. 3. When used in combination with strong diuretics, it can lead to increased renal toxicity. 4. The effect of this drug can be reduced with tetracycline, erythromycin and chloramphenicol. 5. When used with alcohol at the same time, this drug may cause disorder reactions. 6. Cefuroxime can reduce the effect of oral contraceptives, and other effective contraceptive methods should be used. 7. Interference with laboratory test values, the false positive rate of coomds test is high.

Keep away from light, seal tightly, and store in a cool and dry place. Validity period: two years

Calculated as Cefonicid 2.0g

Tianjin Shin Poong Pharmaceutical Co., Ltd.

• Founded in:

  1995-02-24

• Address:

  No. 8, Muning Road, Tianjin Economic and Technological Development Zone

• Tax NO.:

  91120116600587415N

• Registered Funds:

  $9 million

• Email:

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