Ethylamine, pyrazine, and rifampicin tablets (Ⅱ)

Rifampicin is a bactericidal agent in the rifamycin class; isoniazid, pyrazinamide, and ethambutol are anti-tuberculosis bactericidal agents.

Each tablet contains 0.15g of rifampicin (C43H58N4O12), 0.075g of isoniazid (C6H7N3O), 0.4g of pyrazinamide (C5H5N3O), and 0.275g of ethambutol hydrochloride (C10H24N2O2·2HCl).

This product is a film-coated tablet, which appears red after removing the coating.

It is suitable for the initial 2 months of intensive treatment of short-term tuberculosis therapy and must be taken daily during this stage.

Oral administration. Patients weighing 30-37kg should take 2 tablets per day, patients weighing 38-54kg should take 3 tablets per day, patients weighing 55-70kg should take 4 tablets per day, and patients weighing more than 71kg should take 5 tablets per day, one hour before meals. This product is not suitable for patients weighing less than 30kg.

Not yet clear.

1. It is contraindicated for patients who are allergic to rifampicin, pyrazinamide, isoniazid, ethambutol hydrochloride or any excipients; 2. It is contraindicated for patients with abnormal liver function, biliary obstruction, pregnant women under 3 months, gout patients, mental illness, epilepsy patients, diabetic patients with fundus lesions, and porphyria; 3. It is contraindicated for patients with severe renal insufficiency (creatinine clearance <30ml/min); 4. It is contraindicated for use in combination with voriconazole and protease inhibitors (see [Drug Interactions] for details); 5. It is contraindicated for pregnant women in the first 3 months of pregnancy; 6. It is contraindicated for children.

Precautions for children: Children are prohibited from using. Precautions for pregnancy and lactation: Pregnant women in the first 3 months of pregnancy are prohibited from using. Precautions for the elderly: The elderly are often accompanied by physiological renal impairment, so the dosage should be adjusted according to renal function. Or follow the doctor's advice.

1. The effect of other drugs on this product: Antacids can reduce the bioavailability of rifampicin, isoniazid, and ethambutol. To avoid this situation, this product should be taken within 1 hour of taking anti-acids. Corticosteroids can reduce the blood concentration of isoniazid by promoting the metabolism of isoniazid and/or increasing renal clearance. 2. The effect of this product on other drugs: Rifampicin has a strong induction effect on the cytochrome P450 system (CYP450). The cytochrome P450 system is mainly composed of two subfamilies, CYP3A and CYP2C, which account for 80% of the cytochrome P450 system isoenzymes. When used in combination, rifampicin can accelerate the metabolism of the combined drugs. These drugs taken at the same time are partially or completely metabolized by these two isoenzymes. Rifampicin can also induce uridine-

seal.

450 mg (C43H58N4O1275 mg, C6H7N3O37.5 mg, C5H5N3O200 mg and C10H24N2O2·2HCl137.5 mg)

24 months

Zhejiang Sukean Pharmaceutical Co., Ltd.

• Founded in:

  2010-12-21

• Address:

  No. 829, Changfuhang Road, Qianjin Street, Qiantang District, Hangzhou City, Zhejiang Province

• Tax NO.:

  91330100566970364L

• Registered Funds:

  165 million yuan

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