tinidazole

This product has high activity against protozoa and anaerobic bacteria. It has antibacterial activity against Bacteroides fragilis and other Bacteroides, Fusobacterium, Clostridium, Peptococcus, Peptostreptococcus, Veillonella and Gardnerella. A concentration of 2-4 mg/L can inhibit most anaerobic bacteria; microaerophilic bacteria and Helicobacter pylori are sensitive to it; the MIC for Trichomonas vaginalis is similar to that of metronidazole, and its metabolites are more active against Gardnerella than metronidazole. The mechanism of action of this product has not been fully elucidated. The nitroreductase of anaerobic bacteria plays an important role in the energy metabolism of sensitive strains. The nitro group of this product is reduced to a cytotoxin, which acts on the bacterial DNA metabolism process and promotes the death of bacteria. Resistant bacteria often lack nitroreductase and are resistant to this product. The mechanism of this product against amoeba is to inhibit its redox reaction.

1. For various anaerobic infections, such as sepsis, osteomyelitis, abdominal infection, pelvic infection, pulmonary bronchial infection, sinusitis, skin cellulitis, periodontal infection and postoperative wound infection. 2. For preoperative preventive medication for colorectal surgery, gynecological surgery and oral surgery. 3. For the treatment of intestinal and extraintestinal amebiasis, vaginal trichomoniasis, giardiasis, Gardnerella vaginitis, etc. 4. It can also be used as an alternative to metronidazole for the treatment of gastritis and peptic ulcer caused by Helicobacter pylori.

Oral. 1 Anaerobic infection: 1g once, once a day, double the first dose, generally the course of treatment is 5 to 6 days, or determined according to the condition. 2 Prevention of postoperative anaerobic infection: 2g once 12 hours before surgery. 3 Protozoan infection: ① Trichomoniasis, giardiasis: single dose of 2g once, children take 50mg/kg per day, can be repeated once every 3 to 5 days. ② Intestinal amebiasis: 0.5g once, twice a day, course of treatment for 5 to 10 days; or 2g once, once a day, course of treatment for 2 to 3 days; children take 50mg/kg per day according to body weight, once, course of treatment for 3 days. ③ Extraintestinal amebiasis: 2g once, once a day, course of treatment for 3 to 5 days.

It is contraindicated for patients who are allergic to this product or azole drugs and those with active central nervous system diseases and blood diseases.

1 This product can inhibit the metabolism of warfarin and other oral anticoagulants, enhance their effects, and cause prolongation of prothrombin time. 2 When used in combination with drugs that induce liver microsomal enzymes such as phenytoin sodium and phenobarbital, it can accelerate the metabolism of this product, reduce blood drug concentrations, and slow down the excretion of phenytoin sodium. 3 When used in combination with drugs that inhibit the activity of liver microsomal enzymes such as cimetidine, it can slow down the metabolism and excretion of this product in the liver, and prolong the blood elimination half-life (t1/2b) of this product. The dosage should be adjusted according to the results of blood drug concentration determination. 4 This product interferes with the metabolism of disulfiram. When the two are used together, patients may experience mental symptoms after drinking. Therefore, those who have used disulfiram within 2 weeks should not use this product again. 5 This product can interfere with the determination results of serum aminotransferase and lactate dehydrogenase, and can cause bile

Keep away from light and store in sealed container.

API

Hubei Guangji Pharmaceutical Co., Ltd.

• Founded in:

  1993-05-28

• Address:

  No. 100, Meiwu Road, Dajin Town, Wuxue City, Hubei Province

• Tax NO.:

  91420000707016110B

• Registered Funds:

  353.860939 yuan

• Website:

  Log in to view

• Email:

  Log in to view