Phenformin Hydrochloride Tablets

Phenformin hydrochloride is an oral hypoglycemic drug of the biguanide class. This product does not stimulate β cells to secrete insulin, and there is no significant change in blood insulin concentration after medication. The mechanism of action of this product in lowering blood sugar may be: ① Increase the sensitivity of peripheral tissues to insulin and increase insulin-mediated glucose utilization; ② Increase the utilization of glucose by non-insulin-dependent tissues, such as the brain, blood cells, renal medulla, intestines, skin, etc.; ③ Inhibit hepatic gluconeogenesis and reduce hepatic glucose output; ④ Inhibit the uptake of glucose by intestinal wall cells; ⑤ Inhibit the biosynthesis and storage of cholesterol and reduce blood triglyceride and total cholesterol levels. Unlike the action of insulin, this product has no effect on promoting fat synthesis, has no obvious hypoglycemic effect on normal people, and generally does not cause hypoglycemia when used alone for type 2 diabetes.

The main ingredient of this product is: phenformin hydrochloride. Its chemical name is: 1-(2-phenylethyl) biguanide hydrochloride

This product is white tablets.

It is used for patients with type 2 diabetes who are not satisfied with diet control alone, especially those who are obese and have hyperinsulinemia. This drug not only has the effect of lowering blood sugar, but also has the effect of reducing weight and hyperinsulinemia. It can be effective for patients with poor response to certain sulfonylureas. For example, it is more effective when used in combination with sulfonylurea hypoglycemic drugs, intestinal glycosidase inhibitors or thiazolidinedione hypoglycemic drugs than when used alone. It can also be used for patients treated with insulin to reduce the amount of insulin used.

The dosage should be in accordance with the doctor's instructions, and the principle of personalized dosing should be adopted. 1. Dosage method for monotherapy: When starting treatment, it is generally taken orally once a day, 25 mg each time, before meals; after a few days, the frequency of dosing can be increased to 2-3 times, 25 mg each time. 2. When used in combination with sulfonylurea drugs: once a day for the first week, 25 mg each time, before meals; after testing blood sugar in the second week, the frequency of daily dosing can be gradually increased to 23 times a day, 25 mg each time, until blood sugar levels drop to or approach normal values. The maximum daily oral dose of this product generally does not exceed 75 mg, otherwise hyperlactatemia or lactic acidosis is likely to occur; in order to reduce gastrointestinal side effects, this product should be taken with food.

1 Common symptoms include nausea, vomiting, diarrhea, abnormal taste, etc.; 2 Abdominal pain, constipation, bloating, indigestion, heartburn, as well as dizziness, headache, flu-like symptoms, muscle pain, hypotension, palpitations, hot flashes, chills, chest discomfort, rash, weakness, tiredness, etc. may sometimes occur; 3 Although the incidence of lactic acidosis is very low, it should be paid attention to. The clinical manifestations are vomiting, abdominal pain, hyperventilation, mental disorders, etc.; 4 It can reduce the intestinal absorption of vitamin B12, reduce hemoglobin, produce megaloblastic anemia, and may also cause malabsorption.

The following conditions should not be used: 1. Type 2 diabetes accompanied by ketosis, acidosis, liver and kidney dysfunction (serum creatinine exceeds 1.5mg/dl), pulmonary insufficiency, heart failure, respiratory failure, acute myocardial infarction, severe infection and trauma, major surgery, and clinical hypotension and hypoxia. 2. Alcoholics, excessive drinkers, dehydration, dysentery, malnutrition, and those who are allergic to this product and biguanides. 3. Diabetes with severe chronic complications (such as diabetic nephropathy, diabetic fundus lesions). 4. Before intravenous pyelography or arterial angiography. 5. Patients with severe heart and lung diseases. 6.

1. This drug combined with insulin will enhance the hypoglycemic effect, and the insulin dose should be reduced. 2. It can enhance the anticoagulant effect of anticoagulants (such as warfarin), leading to bleeding tendency.

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25mg