Matrine Sodium Chloride Injection

Oxymatrine was observed to have a liver protective effect in experimental liver injury induced by carbon tetrachloride and D-aminolactose. Clinical studies have shown that TNF/TNF-R and Fas/Fasl are the two main systems that mediate PSV hepatotoxicity. The experimental results suggest that oxymatrine blocks the hepatotoxicity of TNF-a by inhibiting M, activating and secreting TNF-a. Oxymatrine can enhance NK cell activity, improve and correct the state of immune disorder, and enhance the ability of the immune system to recognize and eliminate viruses. Animal experiments have shown that intramuscular injection of 200 mg/kg of oxymatrine two days before X-ray irradiation can significantly prevent the decrease in leukocytes in rabbits caused by 60Co irradiation, and also has a significant effect on the decrease in cells in mice caused by irradiation. Studies have shown that oxymatrine scavenges OH free radicals by reacting with OH to form organic free radicals or oxymatrine free radicals, thereby protecting 5'-TMP from radiation damage and exerting an anti-cancer effect. Oxymatrine is an inducer of liver microsomal cytochrome P450, which plays a key role in drug metabolism. When used in combination with cyclophosphamide, it has a synergistic anti-cancer effect. One of the mechanisms is that oxymatrine increases the activation of cyclophosphamide by inducing P450, and when oxymatrine is used in combination with a 1/2 dose of cyclophosphamide, the anti-cancer effect is equivalent to that of the original dose. At the same time, it inhibits the toxicity of cyclophosphamide to leukocytes and significantly reduces the degree of leukopenia.

The main ingredient of this product is matrine, also known as oxymatrine.

This product is a colorless or almost colorless clear liquid.

Used for the treatment of chronic hepatitis B, tumor radiotherapy, chemotherapy-induced leukopenia and leukopenia caused by other reasons.

Intravenous drip. Once a day, 0.4-0.6g each time. 2 months as a course of treatment, or as directed by the doctor.

The incidence of adverse reactions is low. Common adverse reactions include dizziness, nausea, vomiting, bitter taste in the mouth, diarrhea, upper abdominal discomfort or pain, and occasionally rash, chest tightness, and fever. Symptoms generally resolve on their own. Some patients may experience redness at the injection site.

1. Patients who are allergic to this product are prohibited from using it. 2. Patients with severe blood, heart, liver, kidney and endocrine diseases are prohibited from using it.

It has a synergistic effect with central nervous system depressants such as chloral hydrate, an antagonistic effect on central nervous system stimulants such as amphetamine, and can facilitate the convulsive effect of strychnine.

Keep tightly closed.

200ml: 0.6g of oxymatrine (calculated as C15H24N2O2.H20) and 1.8g of sodium chloride

Sichuan Kelun Pharmaceutical Co., Ltd.

• Founded in:

  2002-05-29

• Address:

  South 2nd Road, Xindu Satellite City Industrial Development Zone, Chengdu

• Tax NO.:

  9151010020260067X4

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