Sodium Aescinate for Injection

1. Pharmacology This product can promote the body to increase the plasma concentration of ACTH and cortisone, promote the secretion of PGF2alpha in the blood vessel wall, and remove free radicals in the body, thereby playing an anti-inflammatory and anti-exudative role, improving venous tension, accelerating venous blood flow, promoting lymphatic return, improving blood circulation and microcirculation, and protecting the blood vessel wall. 2. Toxicology No hemolysis was found at a daily dose of less than 0.5 mg per kilogram of body weight. Acute toxicity study: After intravenous injection of the LD50 dose, animals developed acute poisoning, mainly manifested as hemolytic hypoxic necrosis of solid organs (heart, liver, and kidney); it had a strong irritating effect on mucosa and muscle tissue. Chronic toxicity study: A dose equivalent to 1/5 of the LD50 was given intravenously to rabbits every day for 30 consecutive days, and no animal death occurred, and no pathological changes occurred in its solid organs. Teratogenicity test: No teratogenic effect. It was observed that the drug content in the amniotic fluid of pregnant women was high in the first 3 months, so it is recommended that pregnant women should not use it.

The main ingredients of this product are sodium aescinate A and sodium aescinate B, which are triterpenoid saponins containing ester bonds extracted from the dried mature seeds of Aesculus tianshiensis, a plant of the Aesculus family.

It is used for cerebral edema, swelling caused by trauma or surgery, and also for venous reflux disorders.

Intravenous injection or intravenous drip. For adults, take 0.1-0.4 mg/kg per day according to body weight, or take 5-10 mg of this product dissolved in 250 ml of 10% glucose injection or 0.9% sodium chloride injection for intravenous drip; or take 5-10 mg of this product dissolved in 10-20 ml of 10% glucose injection or 0.9% sodium chloride injection for intravenous push injection. For critically ill patients, multiple doses can be given, but the total amount per day should not exceed 20 mg. The course of treatment is 7-10 days.

1. Local pain and swelling may be seen at the injection site, which can disappear with hot compress. 2. Occasionally, allergic reactions may occur, which can be treated according to the principles of drug allergy treatment.

1. It is contraindicated for patients with renal damage, renal failure, or renal insufficiency. 2. It is contraindicated for pregnant women. 3. It is contraindicated for those who are allergic to the ingredients of this product.

Be cautious when using it in combination with the following drugs: 1. Drugs with high binding rate to serum proteins. 2. Drugs that can seriously damage renal function. 3. Corticosteroid drugs. 4. Drugs containing basic groups (precipitation may occur when used in combination).

Keep in a light-proof and airtight container.

10mg

Harbin Zhenbao Pharmaceutical Co., Ltd.

• Founded in:

  2001-12-06

• Address:

  No. 8, Yantai 1st Road, Central District, Haping Road, Harbin Development Zone

• Tax NO.:

  91230199731374049N

• Registered Funds:

  400 million yuan

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