Vecuronium Bromide for Injection

This product is a monoquaternary ammonium steroid medium-acting non-depolarizing muscle relaxant, similar in structure to pancuronium bromide, which blocks the conduction between nerve endings and striated muscles by competing with acetylcholine for nicotinic receptors located at the motor end plate of striated muscles. Unlike depolarizing neuromuscular blocking drugs, such as succinylcholine, this product does not cause muscle fiber bundles to tremble. Intravenous injection of 0.08-0.1mg/kg takes effect within 1 minute, reaches a peak in 3-5 minutes, and lasts for 30-90 minutes. The muscle relaxant effect is 3 times stronger than that of tubocurarine chloride; it has no vagus nerve blocking effect. Since vecuronium bromide does not cause an increase in heart rate, it is suitable for patients with myocardial ischemia and heart disease, but the use of vagus nerve excitants and β-receptor blockers is prone to bradycardia. This product has a weak histamine release effect, and there are also bronchospasm and allergic reactions, but they are rare.

Main ingredients of this product: Vecuronium bromide. C34H57Br2N204 Molecular formula: C34H57Br2N2O4 Molecular weight: 637.74

It is mainly used as an auxiliary drug for general anesthesia, for tracheal intubation during general anesthesia and muscle relaxation during surgery.

This product is only for intravenous injection or intravenous drip, not for intramuscular injection. Solvent: This product can be dissolved in the following injections to a concentration of 1mg/ml for use, sterile water for injection, 5% glucose injection, 0.9% sodium chloride injection, lactated Ringer's solution, glucose sodium chloride injection; Diluent: After this product is dissolved in sterile water for injection, it can be mixed and diluted with the following injections to a concentration of 40mg/L for use, 0.9% sodium chloride injection, 5% glucose injection, Ringer's solution, glucose Ringer's solution. 1 Common dosage for adults; ① The dosage for endotracheal intubation is 0.08-0.12mg/kg, and the intubation state is reached within 3 minutes; ② When maintaining muscle relaxation at the level of neurosedative analgesia anesthesia, it is 0.05mg/kg, and when inhalation anesthesia is 0.03mg/kg. It is best to add a maintenance dose when the twitch height recovers to 25% of the control value. Infants under 21 years old are more sensitive to this product and should be tested in a small amount. The time required for muscle tension recovery is 1.5 times longer than that of adults. Especially for infants under 4 months old, the first dose is 0.01-0.02 mg/kg. If the twitch reaction is not suppressed to 90%-95%, additional doses can be given. The dose required for infants from 5 months to 1 year old is similar to that for adults, but because the effect and recovery time are longer than those for adults and children, the maintenance dose should be reduced as appropriate. Similar to adults, in pediatric patients. When the twitch degree recovers to 25% of the control value, repeat additional 1/4 of the initial dose as a maintenance medication, and no accumulation effect will occur. 3 Reduce the dosage for obese patients; Caesarean section and neonatal surgery should not exceed 0.1 mg/kg.

1. Allergic reactions: ①. Allergic reactions to neuromuscular blocking drugs have been reported. Although this product is rare, it should be noted; ②. Cross-allergic reactions may occur between neuromuscular blocking drugs, so people with a history of allergies should be particularly cautious when using vecuronium. 2. Histamine release and histamine-like reactions: Local or systemic histamine-like reactions may occur occasionally in clinical practice.

Patients with a history of allergy to vecuronium or bromide ion are contraindicated.

1 The following drugs can enhance the effect of this product: ① Inhaled anesthetics such as halothane, enflurane, isoflurane, etc.; ② High-dose thiopental sodium, methylthiobarbital, ketamine, fentanyl, γ-hydroxybutyric acid, etomidate, propofol; ③ Other non-depolarizing muscle relaxants and succinylcholine; ④ Antibiotics such as aminoglycosides, peptides, acylaminopenicillins and high-dose metronidazole; ⑤ Others such as diuretics, β-adrenergic blockers, thiamine, monoamine oxidase inhibitors, quinidine, protamine, α-adrenergic blockers, magnesium salts, etc. 2 The following drugs can weaken the effect of this product: ① Neostigmine, edrophonium, pyridostigmine, aminopyridine derivatives; ② Long-term use of corticosteroids or amide zosin; ③ Norepinephrine, azathioprine (only short-term, limited effect), theophylline, calcium chloride. 3 The following drugs may change the effect of this product: after using vecuronium bromide, giving depolarizing muscle relaxants, such as succinylcholine, may enhance or weaken its neuromuscular blocking effect.

Keep away from light and store in a sealed container.

4mg

Jincheng Haisi Pharmaceutical Co., Ltd.

• Founded in:

  1997-12-30

• Address:

  Wangtai, Jincheng City, Shanxi Province

• Tax NO.:

  91140500111208832X

• Registered Funds:

  148.512131 yuan

• Email:

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