Carbamazepine Capsules

This product is an anticonvulsant and antiepileptic drug. The pharmacological effects of carbamazepine are anticonvulsant, antiepileptic, anti-neuropathic pain, anti-manic-depressive, improvement of symptoms of certain mental illnesses, and anti-central diabetes insipidus. The mechanisms of these effects may be: 1. Use-dependent blocking of various Na channels of excitable cell membranes, so it can significantly inhibit the occurrence and spread of abnormal high-frequency discharges. 2. Inhibit T-type calcium channels. 3. Enhance the activity of central noradrenergic nerves. 4. Promote the secretion of antidiuretic hormone (ADH) or increase the sensitivity of effectors to ADH.

The main ingredient of this product is carbamazepine. Its chemical name is 5H-dibenzo[b,f]azepine-5-carboxamide. Molecular formula: C15H12N2O Molecular weight: 236.27

The content of this product is white or almost white powder.

1. Complex partial seizures (also known as psychomotor seizures or temporal lobe epilepsy), generalized tonic-clonic seizures, the above two mixed seizures or other partial or generalized seizures; ineffective for typical or atypical absence seizures, myoclonic or absence tension seizures. 2. Attacks of trigeminal neuralgia and glossopharyngeal neuralgia. It is also used as a long-term preventive medication after the relief of trigeminal neuralgia. It can also be used for tabes dorsalis and multiple sclerosis, diabetic peripheral neuropathy, pain in the affected limbs, post-traumatic neuralgia and post-herpetic neuralgia. 3. Prevention or treatment of manic-depression; it can be used alone or in combination with lithium salts and other antidepressants for manic-depression that is ineffective or intolerant to lithium, antipsychotics, and antidepressants. 4. Central partial diabetes insipidus. It can be used alone or in combination with chlorpropamide or clofibrate. 5.

Common dosage for adults: 1. Anticonvulsant, start with 0.1g once, 2 to 3 times a day; increase by 0.1g per day after the second day until the effect is seen; the maintenance dose is adjusted to the lowest effective dose, taken in divided doses; pay attention to individualization, the maximum daily dose should not exceed 1.2g. 2. Analgesia, start with 0.1g once, 2 times a day; increase by 0.1 to 0.2g every other day after the second day until the pain is relieved, the maintenance dose is 0.4 to 0.8g per day, taken in divided doses; the maximum daily dose should not exceed 1.2g. 3. Diabetes insipidus, 0.3 to 0.6g per day when used alone. If used in combination with other antidiuretics, 0.2 to 0.4g per day, taken in 3 times. 4. Anti-mania or antipsychotic, start with 0.2 to 0.4g per day, gradually increase to a maximum of 1.6g per week, divided into 3 to 4 doses

1. The more common adverse reactions are reactions of the central nervous system, manifested as blurred vision, diplopia, and nystagmus. 2. Water retention and hyponatremia (or water intoxication) are caused by stimulating the secretion of antidiuretic hormone, with an incidence of about 10% to 15%. 3. Less common adverse reactions include allergic reactions, Stevens-Johnson syndrome or toxic epidermal necrolysis, rash, urticaria, itching; behavioral disorders in children, severe diarrhea, and lupus erythematosus-like syndrome (urticaria, itching, rash, fever, sore throat, bone or joint pain, fatigue). 4. Rare adverse reactions include glandular disease, arrhythmia or atrioventricular block (especially for the elderly), bone marrow suppression, central nervous system poisoning (speech difficulties, mental restlessness, tinnitus, tremors, hallucinations), over-

Contraindications: Patients with a history of atrioventricular block, severe serum iron abnormalities, bone marrow suppression, severe liver dysfunction, etc.

Precautions for children: Anticonvulsant, start with 5mg/kg per day before 6 years old, increase the dosage every 5-7 days to 10mg/kg per day, and increase to 20mg/kg if necessary, and adjust the maintenance dose to maintain a blood concentration of 8-12μg/ml, generally 10-20mg/kg per day, about 0.25-0.35g, usually not more than 0.4g per day; children aged 6-12, 0.1g on the first day, take 2 times, increase 0.1g per day every week until the effect appears; the maintenance dose is adjusted to the minimum effective dose, generally 0.4-0.8g, not more than 1g per day, taken in 3-4 times. Precautions for pregnancy and lactation: This product can pass the placenta, and it is not clear whether it is teratogenic. It should be used with caution in early pregnancy; this product can be secreted into breast milk, with a blood concentration of about 60%, and it is not suitable for lactating women. Precautions for the elderly: Elderly patients are often sensitive to this product, which can often cause cognitive dysfunction, agitation, restlessness, anxiety, mental confusion, atrioventricular block or bradycardia, and can also cause aplastic anemia.

1. When used in combination with acetaminophen, especially in a single overdose or long-term large doses, the risk of liver poisoning increases, which may reduce the efficacy of the latter. 2. When used in combination with coumarin anticoagulants, due to the positive induction of liver enzymes by this product, the blood concentration of anticoagulants is reduced, the half-life is shortened, and the anticoagulant effect is weakened. The prothrombin time should be measured and the dosage should be adjusted. 3. When used in combination with carbonic anhydrase inhibitors, the risk of osteoporosis increases. 4. Due to the liver enzyme induction effect of this product, when used in combination with chlorpropamide, clofibrate (clofibrate), desmopressin, lypressin, vasopressin, vasopressin, etc., the antidiuretic effect can be enhanced, and the dosage of each combined drug needs to be reduced. 5 When used in combination with estrogen-containing contraceptives, cyclosporine, digitalis (except possibly digoxin), estrogen, levothyroxine or quinidine, the effects of these drugs will be reduced due to the positive induction of liver metabolic enzymes by carbamazepine, and the dosage should be adjusted to use oral contraceptives containing only progestin (progesterone). Vaginal bleeding may occur when used in combination with oral contraceptives. 6 When used in combination with doxycycline (doxycycline), the latter's blood concentration may be reduced, and the dosage needs to be adjusted if necessary. 7 Erythromycin, troleandomycin and detropropoxyphene can inhibit the metabolism of carbamazepine, causing the latter's blood concentration to increase and toxic reactions to occur. 8 Haloperidol, loxapine, maprotiline, thioxanthenes or tricyclic antidepressants can enhance the metabolism of carbamazepine, causing the latter's blood concentration to increase and toxic reactions to occur. 9 Lithium salts can reduce the antidiuretic effect of carbamazepine. 10 When used in combination with monoamine oxidase (MAO) inhibitors, it can cause high fever or (and) hypertensive crisis, severe convulsions, and even death. The two drugs should be used at least 14 days apart. When carbamazepine is used as an anticonvulsant, MAO inhibitors can change the type of epileptic seizure. 11 Carbamazepine can reduce the absorption of nomifensine and accelerate its elimination. 12 Phenobarbital and phenytoin accelerate the metabolism of carbamazepine and can reduce the t1/2 of carbamazepine to 9-10 hours.

Keep away from light and store in sealed container.

0.2g

36 months

Jinyao Darrentang Group Co., Ltd. Xinxin Pharmaceutical Factory

• Founded in:

  2000-10-20

• Address:

  Chenglinzhuang Industrial Zone, Tianjin

• Tax NO.:

  91120110103738323L

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