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Amoxicillin and Clavulanate Potassium Chewable Tablets (7:1)

Function and Efficacy

This product is a compound preparation composed of amoxicillin and potassium clavulanate, in which amoxicillin is a semi-synthetic broad-spectrum penicillin antibiotic that mainly acts on the bacterial reproduction stage by inhibiting the biosynthesis of its cell wall mucopolypeptide. It is effective against many Gram-positive and Gram-negative bacteria. Potassium clavulanate has a β-lactam structure similar to penicillin. It has only weak antibacterial activity itself, but it can inactivate enzymes produced by many bacteria by blocking the active site of β-lactamase, especially for clinically important, plasmid-mediated β-lactamases (these enzymes are usually related to changes in resistance to penicillins and cephalosporins). The combination of the two can protect amoxicillin from hydrolysis and destruction by β-lactamase, so that it is still effective against resistant bacteria that produce β-lactamase.

Ingredients

Amoxicillin, clavulanate potassium.

Name Description Content CAS NO. Manufacturer
AmoxicillinIngredients

It is a semi-synthetic broad-spectrum penicillin antibiotic that mainly acts on the bacterial reproduction stage by inhibiting the biosynthesis of cell wall mucopolypeptides. It is effective against many Gram-positive and Gram-negative bacteria.

More
26787-78-0 30
Potassium clavulanateIngredients

It has a β-lactam structure similar to penicillin and has only weak antibacterial activity itself, but it can inactivate enzymes produced by many bacteria by blocking the active site of β-lactamase, especially for clinically important plasmid-mediated β-lactamase (these enzymes are usually related to changes in penicillin and cephalosporin resistance). The combination of the two can protect amoxicillin from hydrolysis and destruction by β-lactamase, so that it is still effective against resistant bacteria that produce β-lactamase.

More
61177-45-5 27

Appearance

This product is white or off-white tablets.

Indication

This product is suitable for various infections caused by sensitive bacteria, such as: 1. Upper respiratory tract infections: sinusitis, tonsillitis, pharyngitis, otitis media, etc. 2. Lower respiratory tract infections: acute bronchitis, acute exacerbation of chronic bronchitis, pneumonia, lung abscess and bronchiectasis combined with infection, etc. 3. Urinary system infections: cystitis, urethritis, pyelonephritis, prostatitis, pelvic inflammatory disease, gonococcal urinary tract infection and soft chancroid, etc. 4. Skin and soft tissue infections: furuncle, abscess, cellulitis, wound infection, intra-abdominal sepsis, etc. 5. Other infections: osteomyelitis, sepsis, peritonitis and postoperative infection, etc.

Usage and Dosage

Oral administration by chewing: Adults and children over 12 years old, 2 tablets at a time, 3 times a day; children aged 7-12 years old, 1.5 tablets at a time, 3 times a day; children aged 1-7 years old, 1 tablet at a time, 3 times a day; children aged 3 months to 1 year old, half a tablet at a time, 3 times a day. In case of severe infection, the dose can be doubled or as directed by the doctor. Continuous treatment should not exceed 14 days without reexamination.

Adverse Reactions

1. A small number of patients may experience mild gastrointestinal adverse reactions such as nausea, vomiting, diarrhea and pseudomembranous colitis. If the above adverse reactions occur, take the medicine with meals, and the above reactions will improve or disappear. 2. Urticaria-like rash is occasionally seen. If urticaria and severe measles-like rash occur, the use of this product should be stopped. 3. A very small number of patients show temporary liver function abnormalities.

Precautions

The product is contraindicated in the following cases: 1. Allergic to any component of this product; 2. Those with a history of allergy to β-lactamase antibiotics such as penicillin.

Storage

Sealed, store in a cool, dry place.

Packaging Specification

0.2285g (C16H19N3O5S 0.2g and C8H9NO5 0.0285g)

Manufacturer

Sichuan Pharmaceutical, Inc.

  • Founded in:

    2005-07-14
  • Address:

    No. 18, Baiye Road, High-tech West District, Chengdu
  • Tax NO.:

    91510100777457202W
  • Registered Funds:

    80 million yuan
  • Website:

  • Email:

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