Erythromycin Cyclopentyl Tablets

Pharmacological action: Cyclic erythromycin belongs to the macrolide antibiotics. It acts on the 50S subunit of bacterial cell ribosomes and inhibits the synthesis of bacterial proteins. Cyclic erythromycin is a semi-synthetic derivative of erythromycin. The introduction of the cyclic carbonate group greatly improves the lipophilicity of erythromycin, thereby increasing its absorption. Experiments have shown that this structural change reduces the serum protein binding rate, improves the antibacterial activity and reduces the toxicity. This product has a broad antibacterial spectrum and is effective against the following bacteria: Gram-positive bacteria: Staphylococcus aureus, Streptococcus pyogenes, Pneumococcus, Corynebacterium diphtheriae, etc. Gram-negative bacteria: Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Shigella, etc. In addition to Bacteroides fragilis and Fusobacterium, it also has considerable antibacterial activity against various anaerobic bacteria. It also has certain therapeutic effects on other microorganisms: Mycoplasma, Chlamydia, Spirochete, Legionella, Campylobacter, Ameba, etc.

Erythromycin cyclic 11,12-carbonate.

This product is a white round biconvex tablet.

Infections caused by sensitive bacteria, such as tonsillitis, pharyngitis, bacterial pneumonia, mycoplasma pneumonia, stomatitis, Legionnaires' disease, diphtheria, whooping cough, scarlet fever, erythrasma, erysipelas, gonorrhea, early syphilis, chancroid, urethritis, Campylobacter enteritis, amoebic enteritis, etc.

Take once every 12 hours on an empty stomach. Adults: 500-700 mg (2-3 tablets) for the first dose, followed by 250-500 mg (1-2 tablets) after 12 hours. The dose can be doubled for patients with severe infection. Children: 30 mg/kg body weight for the first dose, followed by 15 mg/kg body weight after 12 hours.

This product is well tolerated, but the following adverse reactions are occasionally seen: 1. Gastrointestinal dysfunction: such as nausea, vomiting, and diarrhea. 2. Allergic reactions: such as rash, eosinophilia, and fever. 3. Reversible hearing loss. 4. Long-term and repeated use may cause overgrowth of insensitive bacteria (such as Clostridium difficile) and fungi.

It is contraindicated in patients who are allergic to macrolide drugs.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Use with caution in pregnant or lactating women. Precautions for the elderly: Follow doctor's advice.

This product will cause drug interactions when taken with the following drugs at the same time. 1. Theophylline: The serum concentration and toxicity of theophylline will increase. Patients receiving this product should reduce the dosage of theophylline. 2. Digoxin: The serum concentration and absorption of digoxin will increase. 3. Cyclosporine A: The serum concentration and renal toxicity of cyclosporine A will increase. 4. Coumarin anticoagulants: The effects of this type of drug will increase. 5. This product will produce antagonistic effects when used in combination with lincomycin or clindamycin.

Sealed, store in a cool, dry place.

0.25g (250,000 units)

36 months

China Resources Double-Crane Pharmaceutical Co., Ltd.

• Founded in:

  1997-05-16

• Address:

  No. 1, Lize East 2nd Road, Wangjing, Chaoyang District, Beijing

• Tax NO.:

  91110000633796475U

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  1,038,836,522 yuan

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