Epalrestat Tablets
Function and Efficacy
Epalrestat is a reversible non-competitive inhibitor of aldose reductase, which has a selective inhibitory effect on aldose reductase. Clinical studies have shown that epalrestat can inhibit the accumulation of sorbitol in erythrocytes of patients with diabetic peripheral neuropathy, and can significantly improve the subjective symptoms and neurological dysfunction of patients compared with the control group. Animal experiments have shown that epalrestat can significantly inhibit the accumulation of sorbitol in the sciatic nerve, erythrocytes, and retina of diabetic model rats, and improve their motor nerve conduction velocity and autonomic nerve function; in terms of nerve morphology, epalrestat can improve axonal flow abnormalities, increase the density of myelinated nerve fibers in the sciatic nerve, the thickness of the sural nerve myelin sheath, the axon area, and the axon cylindrical rate; in addition, epalrestat can also improve the blood flow of the sciatic nerve of the model animal and restore its inositol content.
Ingredients
The main ingredient of this product is: epalrestat.
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| EpalrestatIngredients |
Epalrestat is a reversible non-competitive inhibitor of aldose reductase, which has a selective inhibitory effect on aldose reductase. It can inhibit the accumulation of sorbitol in the red blood cells of patients with diabetic peripheral neuropathy, and improve the patients' subjective symptoms and neurological dysfunction. Animal experiments have shown that epalrestat can significantly inhibit the accumulation of sorbitol in the sciatic nerve, red blood cells, and retina of diabetic model rats, increase motor nerve conduction velocity and autonomic nerve function, improve axonal flow abnormalities, increase the density of myelinated nerve fibers in the sciatic nerve, the thickness of the sural nerve myelin sheath, the axon area, and the axon cylindrical rate, improve the blood flow of the sciatic nerve and restore its inositol content. More |
82159-09-9 | 18 |
Appearance
This product is a film-coated tablet, which appears orange after removing the coating.
Indication
No data yet
Usage and Dosage
The usual adult dose is 50 mg (1 tablet) 3 times a day, taken orally before meals.
Adverse Reactions
1. Allergy: Occasionally erythema, blisters, rash, itching. 2. Liver: Occasionally elevated bilirubin, GPT (ALT), GOT (AST), γ-GPT (GGT). 3. Digestive system: Occasionally diarrhea, nausea, vomiting, abdominal pain, loss of appetite, abdominal distension, stomach discomfort. 4. Kidney: Occasionally elevated creatinine. 5. Others: Very rarely dizziness, vertigo, neck pain, fatigue, drowsiness, edema, swelling and pain, limb pain, numbness, and hair loss.
Precautions
This experiment has not been conducted and there are no reliable references.
Special Population Medication
Precautions for children: There is no experience on the safety of medication for children. Precautions for pregnancy and lactation: There is currently no safety data for this product for pregnant women, so pregnant women should be extremely cautious when using this product and weigh the pros and cons before deciding whether to use it. Animal experiments have shown that epalrestat can be excreted through breast milk, so breastfeeding women should avoid using this product. Precautions for the elderly: Elderly patients should consider appropriate reductions when using this product due to changes in physiological functions.
Drug Interactions
Not yet clear.
Storage
seal.
Packaging Specification
50mg
Validity Period
December
Manufacturer
China Resources Zizhu Pharmaceutical Co., Ltd.
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Founded in:
1980-11-26 -
Address:
Building 18, No. 27 Chaoyang North Road, Chaoyang District, Beijing -
Tax NO.:
91110000101939631P -
Registered Funds:
660.6396 million yuan -
Website:
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Email: