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Cephalexin and Trimethoprim Capsules

Function and Efficacy

This product inhibits bacterial transpeptidase, prevents the synthesis of bacterial cell walls, and inhibits or kills bacteria. The combination of cephalexin and trimethoprim improves the antibacterial ability, delays the development of drug resistance, and reduces the oral dose.

Ingredients

Each tablet contains 125mg of cephalexin and 25mg of trimethoprim

Name Description Content CAS NO. Manufacturer
CephalexinIngredients

By inhibiting bacterial transpeptidase, it prevents the synthesis of bacterial cell walls and inhibits or kills bacteria; when used in combination with trimethoprim, it can enhance antibacterial ability, delay the development of drug resistance, and reduce oral dosage.

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15686-71-2 33
TrimethoprimIngredients

By inhibiting bacterial transpeptidase, it prevents the synthesis of bacterial cell walls and inhibits or kills bacteria; when used in combination with cephalexin, it can enhance antibacterial ability, delay the development of drug resistance, and reduce oral dosage.

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738-70-5 44

Appearance

This product is a capsule, and the contents are white or off-white granules and powder.

Indication

Used for infections caused by penicillin-resistant Staphylococci, Streptococci, Pneumococci, Escherichia coli, etc.

Usage and Dosage

It is recommended to be taken orally on an empty stomach. Adults take 1-2 tablets at a time, 4 times a day. Children should take a reduced dosage or follow the doctor's advice.

Adverse Reactions

1. Nausea, vomiting, diarrhea and abdominal discomfort are more common. 2. Allergic reactions such as rash and drug fever are rare, and anaphylactic shock may occur occasionally. 3. Neurological reactions such as dizziness, diplopia, tinnitus, and convulsions. 4. Renal damage may occur occasionally during the use of this product. 5. Occasionally, patients have elevated serum aminotransferases and positive Coombs tests. Hemolytic anemia is rare. Neutropenia and pseudomembranous colitis have also been reported. 6. Trimethoprim's interference with folic acid metabolism can produce adverse reactions in the blood system, such as leukopenia, thrombocytopenia or methemoglobin anemia. Generally, leukopenia and thrombocytopenia are mild, and can be recovered by stopping the drug in time. Folic acid preparations can also be added.

Precautions

Notes: 1. Cephalosporins and penicillin have some cross-sensitivity. Patients who are allergic to penicillin should use with caution. Patients who are allergic to cephalosporin antibiotics are prohibited from using this product. 2. Patients with renal insufficiency should reduce the dosage as appropriate. 3. False positive urine sugar test may occur when using this product.

Special Population Medication

Precautions for children: It is forbidden to use in newborns and premature infants. Precautions for pregnancy and lactation: This product can pass through the placenta and be excreted through breast milk, so pregnant and lactating women should use it with caution. Precautions for the elderly: This experiment has not been conducted and there is no reliable reference literature.

Drug Interactions

1. When used in combination with cholestyramine (cholestyramine), the average blood concentration of cephalexin can be reduced. 2. Probenecid can delay the renal excretion of this product, and there are also reports that probenecid can increase the excretion of this product in bile. 3. The chance of leukopenia and thrombocytopenia increases when bone marrow suppressants are used in combination with this product. 4. This product should not be used simultaneously with the anti-tumor drug 2,4-diaminopyrimidine drugs, nor should it be used between courses of treatment with other folic acid antagonists, because it may cause bone marrow hypoplasia or megaloblastic anemia. 5. Co-use of cyclosporine can increase renal toxicity.

Storage

Keep in a dark, sealed and cool place

Packaging Specification

Cephalexin 62.5mg, trimethoprim 12.5mg

Validity Period

24 months

Manufacturer

Liaoning Huarui United Pharmaceutical Co., Ltd.

  • Founded in:

    2002-07-30
  • Address:

    No. 1, Park Road, Tongyuanbao Economic Development Zone, Dandong, Liaoning Province
  • Tax NO.:

    91210682740785835Q
  • Registered Funds:

    20.4082 million yuan
  • Email:

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