Danazol Capsules

1. It is a gonadotropin inhibitor that can inhibit the pituitary-ovarian axis. 2. Due to the inhibition of pituitary gonadotropin, the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) is reduced. 3. It can directly inhibit the production of ovarian steroid hormones, act on the estrogen receptor sites of endometrial cells, and have the effect of inhibiting estrogen, causing normal and abnormal endometrium of the uterus to atrophy and become inactive, leading to anovulation and amenorrhea, which can last up to 6-8 months. 5. In the treatment of fibrous breast disease, it can make nodules disappear, relieve pain and tenderness, and may cause menstrual disorders or amenorrhea. 6. When treating hereditary angioedema, it increases the level of serum C1 lipase inhibitor, leading to an increase in the concentration of C4 in the complement system in the serum.

Main ingredients: The main ingredient of this product is danazol. Its chemical name is 17-pregnane-2,4-diene-20-yn-[2,3-d]isoxazol-17-ol. Molecular formula: C22H37NO2 Molecular weight: 337.46

The content of this product is white or off-white crystals or crystalline powder.

It is used to treat endometriosis, and can also be used to treat fibrocystic breast disease, spontaneous thrombocytopenic purpura, hereditary angioedema, systemic erythema, male gynecomastia, and precocious puberty.

Common oral dosage for adults: 1 Endometriosis, 400-800 mg per day, divided into two doses, for 3-6 months. If symptoms recur after discontinuation of medication, another course of treatment can be given (under normal liver function). 2 Fibrocystic breast disease, take medication on the first day after menstruation, 50-200 mg once, twice a day. If symptoms recur within one year after discontinuation of medication, medication can be given again. 3 Hereditary angioedema, start with 200 mg once, 2-3 times a day, until the effect appears. The maintenance dose is generally 50% or less of the initial dose, and it is decreased at intervals of 1-3 months or longer, depending on the frequency of the disease before treatment.

1. More common adverse reactions: amenorrhea, breakthrough uterine bleeding, and may also cause breast reduction, hoarseness, and increased hair growth; acne, increased oiliness of the skin or hair, lower limb edema, or weight gain may occur. Symptoms are related to the dosage and are manifestations of androgen effects. 2. Less common adverse reactions: hematuria, epistaxis, gingival bleeding, cataracts (gradually blurred vision), abnormal liver function, increased intracranial pressure (manifested as severe headache, decreased vision, diplopia, vomiting), leukocytosis, acute pancreatitis, multiple neuritis, etc. 3. Rare adverse reactions include: enlarged clitoris in women and reduced testicles in men; when liver function is severely impaired, both men and women may experience yellowing of the sclera or skin. 4. The following reactions require attention if they persist: (1) Due to the low efficacy of estrogen, it may cause

It is contraindicated for patients with thrombosis, heart, liver, and kidney diseases, and abnormal genital bleeding.

Precautions for children: Precautions for pregnancy and lactation: Pregnant women should not use this drug. Pregnant women should terminate the pregnancy during medication. Theoretically, this product may have androgenic effects on female fetuses, and lactating women should not take it. Precautions for the elderly: Generally, elderly patients have low physiological functions and should take a reduced dose (such as 100mg-200mg per day).

1. When used with insulin, it is easy to develop drug resistance. 2. When used with warfarin, the anticoagulant effect is enhanced, which is easy to cause bleeding.

Keep away from light and store in sealed container.

0.1 g